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pubmed-article:9972855pubmed:abstractTextIt has been hypothesized that environmental stimuli previously paired with ethanol consumption play a role in excessive ethanol intake. This study examined the ability of orally self-administered ethanol to establish a tone-light stimulus complex as a conditioned reinforcer (CSR). Male Long-Evans rats were trained to orally self-administer 10% ethanol (10E) using the sucrose-substitution procedure. During training, a tone-light stimulus complex was paired with ethanol presentation in a stimulus complex paired (SC-paired) group but not in a control group. Responding during extinction in the presence and absence of the stimulus complex was then examined. Following the initiation of ethanol self-administration, 10E maintained greater responding in the SC-paired group compared to the control group. When the stimulus complex was presented contingent on responding during extinction, the rate of extinction was slightly attenuated in the SC-paired group but not in the control group. The altered rate of extinction in the SC-paired group was characterized by: 1) a slight decrease in total session responding over successive days of extinction and 2) a transient attenuation of extinction burst response rate during the first extinction session. These data suggest the stimulus complex could function as a weak CS(R), but overall its ability to maintain lever pressing was minimal.lld:pubmed
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pubmed-article:9972855pubmed:authorpubmed-author:SamsonH HHHlld:pubmed
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pubmed-article:9972855pubmed:volume62lld:pubmed
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pubmed-article:9972855pubmed:pagination127-35lld:pubmed
pubmed-article:9972855pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:9972855pubmed:year1999lld:pubmed
pubmed-article:9972855pubmed:articleTitlePresentation of an ethanol-paired stimulus complex alters response patterns during extinction.lld:pubmed
pubmed-article:9972855pubmed:affiliationDepartment of Physiology and Pharmacology, The Wake Forest University School of Medicine, Winston-Salem, NC 27157-1083, USA.lld:pubmed
pubmed-article:9972855pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9972855pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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