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pubmed-article:9951847pubmed:abstractTextIn vitro data have indicated that tamoxifen (> 2.5 uM) significantly enhances the cytotoxic effect of doxorubicin in hepatocellular carcinoma (HCC) cells. This clinical study was conducted to examine whether tamoxifen, at a dose sufficient to result in a plasma concentration of more than 2.5 uM, may improve the therapeutic efficacy of doxorubicin in patients with advanced HCC.lld:pubmed
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pubmed-article:9951847pubmed:articleTitleBiochemical modulation of doxorubicin by high-dose tamoxifen in the treatment of advanced hepatocellular carcinoma.lld:pubmed
pubmed-article:9951847pubmed:affiliationDepartment of Internal Medicine, National Taiwan University Hospital, Taipei.lld:pubmed
pubmed-article:9951847pubmed:publicationTypeJournal Articlelld:pubmed
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pubmed-article:9951847pubmed:publicationTypeClinical Trial, Phase IIlld:pubmed