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pubmed-article:9934457pubmed:abstractTextAminoglycoside 3'-phosphotransferase type IIa [APH(3')-IIa] is a member of the family of bacterial aminoglycoside-modifying enzymes. Bacteria that harbor these enzymes are resistant to aminoglycoside antibiotics. Four aminoglycoside-based affinity inactivators were synthesized and were shown to be both substrates and inactivators for APH(3')-IIa. These affinity inactivators are N-bromoacetylated derivatives of neamine, an aminoglycoside antibiotic, where the bromoacetyl moiety in each was introduced regiospecifically at a different amine of the parent compound.lld:pubmed
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pubmed-article:9934457pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:9934457pubmed:articleTitleThe use of neamine as a molecular template: inactivation of bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa.lld:pubmed
pubmed-article:9934457pubmed:affiliationDepartment of Chemistry, Wayne State University, Detroit, MI 48202, USA.lld:pubmed
pubmed-article:9934457pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9934457pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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