The proximal tyrosines of the cytoplasmic domain of the beta chain of the type I interferon receptor are essential for signal transducer and activator of transcription (Stat) 2 activation. Evidence that two Stat2 sites are required to reach a threshold of interferon alpha-induced Stat2 tyrosine phosphorylation that allows normal formation of interferon-stimulated gene factor 3.
Source:http://linkedlifedata.com/resource/pubmed/id/9933596
J. Biol. Chem.
1999
Feb
12
274
7
4045-52
