| pubmed-article:9930766 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9930766 | lifeskim:mentions | umls-concept:C0927232 | lld:lifeskim |
| pubmed-article:9930766 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:9930766 | lifeskim:mentions | umls-concept:C0023870 | lld:lifeskim |
| pubmed-article:9930766 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:9930766 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:9930766 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:9930766 | lifeskim:mentions | umls-concept:C0080356 | lld:lifeskim |
| pubmed-article:9930766 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:9930766 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9930766 | pubmed:dateCreated | 1999-2-11 | lld:pubmed |
| pubmed-article:9930766 | pubmed:abstractText | Differential display of mRNA was used to identify concordant changes in gene expression induced by two mood-stabilizing agents, lithium and valproate (VPA). Both treatments, on chronic administration, increased mRNA levels of the transcription factor polyomavirus enhancer-binding protein (PEBP) 2beta in frontal cortex (FCx). Both treatments also increased the DNA binding activity of PEBP2 alphabeta and robustly increased the levels of bcl-2 (known to be transcriptionally regulated by PEBP2) in FCx. Immunohistochemical studies revealed a marked increase in the number of bcl-2-immunoreactive cells in layers 2 and 3 of FCx. These novel findings represent the first report of medication-induced increases in CNS bcl-2 levels and may have implications not only for mood disorders, but also for long-term treatment of various neurodegenerative disorders. | lld:pubmed |
| pubmed-article:9930766 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9930766 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9930766 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9930766 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9930766 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9930766 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9930766 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9930766 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9930766 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9930766 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9930766 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9930766 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:9930766 | pubmed:author | pubmed-author:ChenGG | lld:pubmed |
| pubmed-article:9930766 | pubmed:author | pubmed-author:ZhaoZ HZH | lld:pubmed |
| pubmed-article:9930766 | pubmed:author | pubmed-author:JiangY MYM | lld:pubmed |
| pubmed-article:9930766 | pubmed:author | pubmed-author:ZengW ZWZ | lld:pubmed |
| pubmed-article:9930766 | pubmed:author | pubmed-author:ManjiH KHK | lld:pubmed |
| pubmed-article:9930766 | pubmed:author | pubmed-author:YuanP XPX | lld:pubmed |
| pubmed-article:9930766 | pubmed:author | pubmed-author:HuangL DLD | lld:pubmed |
| pubmed-article:9930766 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9930766 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:9930766 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9930766 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9930766 | pubmed:pagination | 879-82 | lld:pubmed |
| pubmed-article:9930766 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9930766 | pubmed:meshHeading | pubmed-meshheading:9930766-... | lld:pubmed |
| pubmed-article:9930766 | pubmed:meshHeading | pubmed-meshheading:9930766-... | lld:pubmed |
| pubmed-article:9930766 | pubmed:meshHeading | pubmed-meshheading:9930766-... | lld:pubmed |
| pubmed-article:9930766 | pubmed:meshHeading | pubmed-meshheading:9930766-... | lld:pubmed |
| pubmed-article:9930766 | pubmed:meshHeading | pubmed-meshheading:9930766-... | lld:pubmed |
| pubmed-article:9930766 | pubmed:meshHeading | pubmed-meshheading:9930766-... | lld:pubmed |
| pubmed-article:9930766 | pubmed:meshHeading | pubmed-meshheading:9930766-... | lld:pubmed |
| pubmed-article:9930766 | pubmed:meshHeading | pubmed-meshheading:9930766-... | lld:pubmed |
| pubmed-article:9930766 | pubmed:meshHeading | pubmed-meshheading:9930766-... | lld:pubmed |
| pubmed-article:9930766 | pubmed:meshHeading | pubmed-meshheading:9930766-... | lld:pubmed |
| pubmed-article:9930766 | pubmed:meshHeading | pubmed-meshheading:9930766-... | lld:pubmed |
| pubmed-article:9930766 | pubmed:meshHeading | pubmed-meshheading:9930766-... | lld:pubmed |
| pubmed-article:9930766 | pubmed:meshHeading | pubmed-meshheading:9930766-... | lld:pubmed |
| pubmed-article:9930766 | pubmed:meshHeading | pubmed-meshheading:9930766-... | lld:pubmed |
| pubmed-article:9930766 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9930766 | pubmed:articleTitle | The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. | lld:pubmed |
| pubmed-article:9930766 | pubmed:affiliation | Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. | lld:pubmed |
| pubmed-article:9930766 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9930766 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:361391 | entrezgene:pubmed | pubmed-article:9930766 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9930766 | lld:pubmed |
