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| pubmed-article:9927615 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:9927615 | lifeskim:mentions | umls-concept:C0034830 | lld:lifeskim |
| pubmed-article:9927615 | lifeskim:mentions | umls-concept:C0016904 | lld:lifeskim |
| pubmed-article:9927615 | lifeskim:mentions | umls-concept:C0017890 | lld:lifeskim |
| pubmed-article:9927615 | lifeskim:mentions | umls-concept:C0034838 | lld:lifeskim |
| pubmed-article:9927615 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:9927615 | lifeskim:mentions | umls-concept:C0237876 | lld:lifeskim |
| pubmed-article:9927615 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:9927615 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9927615 | pubmed:dateCreated | 1999-3-11 | lld:pubmed |
| pubmed-article:9927615 | pubmed:abstractText | In the present study, we provide evidence that the alpha9 nicotinic acetylcholine receptor (nAChR) shares pharmacological properties with members of the Cys-loop family of receptors. Thus, the type A gamma-aminobutyric acid receptor antagonist bicuculline, the glycinergic antagonist strychnine, and the type 3 serotonin receptor antagonist ICS-205,930 block ACh-evoked currents in alpha9-injected Xenopus laevis oocytes with the following rank order of potency: strychnine > ICS-205,930 > bicuculline. Block by antagonists was reflected in an increase in the acetylcholine (ACh) EC50 value, with no changes in agonist maximal response or Hill coefficient, which suggests a competitive type of block. Moreover, whereas neither gamma-aminobutyric acid nor glycine modified ACh-evoked currents, serotonin blocked responses to ACh in a concentration-dependent manner. The present results suggest that the alpha9 nAChR must conserve in its primary structure some residues responsible for ligand binding common to other Cys-loop receptors. In addition, it adds further evidence that the alpha9 nAChR and the cholinergic receptor present at the base of cochlear outer hair cells have similar pharmacological properties. | lld:pubmed |
| pubmed-article:9927615 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9927615 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9927615 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9927615 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9927615 | pubmed:issn | 0026-895X | lld:pubmed |
| pubmed-article:9927615 | pubmed:author | pubmed-author:KatzEE | lld:pubmed |
| pubmed-article:9927615 | pubmed:author | pubmed-author:ElgoyhenA BAB | lld:pubmed |
| pubmed-article:9927615 | pubmed:author | pubmed-author:RothlinC VCV | lld:pubmed |
| pubmed-article:9927615 | pubmed:author | pubmed-author:VerbitskyMM | lld:pubmed |
| pubmed-article:9927615 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9927615 | pubmed:volume | 55 | lld:pubmed |
| pubmed-article:9927615 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9927615 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9927615 | pubmed:pagination | 248-54 | lld:pubmed |
| pubmed-article:9927615 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9927615 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9927615 | pubmed:articleTitle | The alpha9 nicotinic acetylcholine receptor shares pharmacological properties with type A gamma-aminobutyric acid, glycine, and type 3 serotonin receptors. | lld:pubmed |
| pubmed-article:9927615 | pubmed:affiliation | Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas-Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina. | lld:pubmed |
| pubmed-article:9927615 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9927615 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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