| pubmed-article:9927446 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9927446 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:9927446 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:9927446 | lifeskim:mentions | umls-concept:C1444783 | lld:lifeskim |
| pubmed-article:9927446 | lifeskim:mentions | umls-concept:C1419348 | lld:lifeskim |
| pubmed-article:9927446 | lifeskim:mentions | umls-concept:C0441587 | lld:lifeskim |
| pubmed-article:9927446 | lifeskim:mentions | umls-concept:C0175721 | lld:lifeskim |
| pubmed-article:9927446 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:9927446 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:9927446 | lifeskim:mentions | umls-concept:C0403151 | lld:lifeskim |
| pubmed-article:9927446 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9927446 | pubmed:dateCreated | 1999-3-9 | lld:pubmed |
| pubmed-article:9927446 | pubmed:abstractText | The RFC1 gene encodes the large subunit of the yeast clamp loader (RFC) that is a component of eukaryotic DNA polymerase holoenzymes. We identified a mutant allele of RFC1 (rfc1::Tn3) from a large collection of Saccharomyces cerevisiae mutants that were inviable when present in a rad52 null mutation background. Analysis of rfc1::Tn3 strains indicated that they displayed both a mutator and repeat-tract instability phenotype. Strains bearing this allele were characterized in combination with mismatch repair (msh2Delta, pms1Delta), double-strand break repair (rad52), and DNA replication (pol3-01, pol30-52, rth1Delta/rad27Delta) mutations in both forward mutation and repeat-tract instability assays. This analysis indicated that the rfc1::Tn3 allele displays synthetic lethality with pol30, pol3, and rad27 mutations. Measurement of forward mutation frequencies in msh2Delta rfc1:Tn3 and pms1Delta rfc1:Tn3 strains indicated that the rfc1::Tn3 mutant displayed a mutation frequency that appeared nearly multiplicative with the mutation frequency exhibited by mismatch-repair mutants. In repeat-tract instability assays, however, the rfc1::Tn3 mutant displayed a tract instability phenotype that appeared epistatic to the phenotype displayed by mismatch-repair mutants. From these data we propose that defects in clamp loader function result in DNA replication errors, a subset of which are acted upon by the mismatch-repair system. | lld:pubmed |
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| pubmed-article:9927446 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9927446 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9927446 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9927446 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9927446 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:9927446 | pubmed:author | pubmed-author:XieYY | lld:pubmed |
| pubmed-article:9927446 | pubmed:author | pubmed-author:AlaniEE | lld:pubmed |
| pubmed-article:9927446 | pubmed:author | pubmed-author:CounterCC | lld:pubmed |
| pubmed-article:9927446 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9927446 | pubmed:volume | 151 | lld:pubmed |
| pubmed-article:9927446 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9927446 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9927446 | pubmed:pagination | 499-509 | lld:pubmed |
| pubmed-article:9927446 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9927446 | pubmed:meshHeading | pubmed-meshheading:9927446-... | lld:pubmed |
| pubmed-article:9927446 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9927446 | pubmed:articleTitle | Characterization of the repeat-tract instability and mutator phenotypes conferred by a Tn3 insertion in RFC1, the large subunit of the yeast clamp loader. | lld:pubmed |
| pubmed-article:9927446 | pubmed:affiliation | Section of Genetics and Development, Cornell University, Ithaca, New York 14853-2703, USA. | lld:pubmed |
| pubmed-article:9927446 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9927446 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9927446 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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