| pubmed-article:9927185 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9927185 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:9927185 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:9927185 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:9927185 | lifeskim:mentions | umls-concept:C1660149 | lld:lifeskim |
| pubmed-article:9927185 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:9927185 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9927185 | pubmed:dateCreated | 1999-2-16 | lld:pubmed |
| pubmed-article:9927185 | pubmed:abstractText | Human and mouse fibroblasts with normal p53 fail to enter mitosis when DNA synthesis is blocked by aphidicolin or hydroxyurea. Isogenic p53-null fibroblasts do enter mitosis with incompletely replicated DNA, revealing that p53 contributes to a checkpoint that ensures that mitosis does not occur until DNA synthesis is complete. When treated with N-(phosphonacetyl)-L-aspartate (PALA), which inhibits pyrimidine nucleotide synthesis, leading to synthesis of damaged DNA from highly unbalanced dNTP pools, p53-null cells enter mitosis after they have completed DNA replication, but cells with wild-type p53 do not, revealing that p53 also mediates a checkpoint that monitors the quality of newly replicated DNA. | lld:pubmed |
| pubmed-article:9927185 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9927185 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9927185 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9927185 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9927185 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9927185 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:9927185 | pubmed:author | pubmed-author:StarkG RGR | lld:pubmed |
| pubmed-article:9927185 | pubmed:author | pubmed-author:StaceyD WDW | lld:pubmed |
| pubmed-article:9927185 | pubmed:author | pubmed-author:AgarwalM LML | lld:pubmed |
| pubmed-article:9927185 | pubmed:author | pubmed-author:AgarwalAA | lld:pubmed |
| pubmed-article:9927185 | pubmed:author | pubmed-author:TaylorW RWR | lld:pubmed |
| pubmed-article:9927185 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9927185 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:9927185 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:9927185 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9927185 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9927185 | pubmed:pagination | 283-95 | lld:pubmed |
| pubmed-article:9927185 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9927185 | pubmed:meshHeading | pubmed-meshheading:9927185-... | lld:pubmed |
| pubmed-article:9927185 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9927185 | pubmed:articleTitle | p53 inhibits entry into mitosis when DNA synthesis is blocked. | lld:pubmed |
| pubmed-article:9927185 | pubmed:affiliation | Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio 44195, USA. | lld:pubmed |
| pubmed-article:9927185 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9927185 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9927185 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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