| pubmed-article:9920291 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9920291 | lifeskim:mentions | umls-concept:C0039617 | lld:lifeskim |
| pubmed-article:9920291 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9920291 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9920291 | lifeskim:mentions | umls-concept:C0039067 | lld:lifeskim |
| pubmed-article:9920291 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:9920291 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9920291 | lifeskim:mentions | umls-concept:C1621749 | lld:lifeskim |
| pubmed-article:9920291 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9920291 | pubmed:dateCreated | 1999-2-11 | lld:pubmed |
| pubmed-article:9920291 | pubmed:abstractText | Tetanus toxin (TeTx) is a powerful clostridial neurotoxin that inhibits Ca2+-dependent neurotransmitter secretion as do the botulinum neurotoxins (BoNTs). We found that TeTx (but not BoNT/A) produced a specific time- and dose-dependent inhibition of Na+-dependent [3H]5-hydroxytryptamine (serotonin, 5-HT) uptake in rat CNS synaptosomes. This effect was found in all CNS tryptaminergic areas, being maximal in the hippocampus and occipital cortex. TeTx produced the maximum reduction in [3H]5-HT uptake after 30 min of preincubation, being significant also at lower doses (10(-12) M) or shorter incubation times (10 min). Serotonin transport inhibitors such as fenfluramine (IC50, 11.0 +/- 0.9 microM), paroxetine (IC50, 33.5 +/- 0.1 microM), and imipramine (IC50, 89.9 +/- 5.7 microM) were 3 or 4 orders of magnitude less potent than TeTx (IC50, 8.7 +/- 1.0 nM). Of the two fragments of TeTx, (the C-terminal portion of the neurotoxin heavy chain, which is responsible for the binding to the nerve tissue) was consistently more effective than the L-H(N) fragment (the light neurotoxin chain disulfide linked to the N-terminal portion of the heavy chain, which is responsible for the toxic metalloprotease action) as inhibitor of [3H]5-HT uptake in synaptosomal preparations (56 +/- 5% and 95 +/- 3% with respect to control, respectively). Antagonism of the toxin-induced [3H]5-HT uptake blockade could not be reversed by zinc chelators but did have the ability to antagonize the TeTx inhibition of basal and K+-evoked [3H]5-HT release in rat synaptosomes. The reduction in serotonin accumulation induced by TeTx could be responsible for some tetanic symptoms that have been related to the serotonergic system. | lld:pubmed |
| pubmed-article:9920291 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9920291 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920291 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9920291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920291 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9920291 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9920291 | pubmed:issn | 0006-2952 | lld:pubmed |
| pubmed-article:9920291 | pubmed:author | pubmed-author:GilCC | lld:pubmed |
| pubmed-article:9920291 | pubmed:author | pubmed-author:AguileraJJ | lld:pubmed |
| pubmed-article:9920291 | pubmed:author | pubmed-author:NajibAA | lld:pubmed |
| pubmed-article:9920291 | pubmed:author | pubmed-author:PelliccioniPP | lld:pubmed |
| pubmed-article:9920291 | pubmed:author | pubmed-author:InserteJJ | lld:pubmed |
| pubmed-article:9920291 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9920291 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9920291 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:9920291 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9920291 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9920291 | pubmed:pagination | 111-20 | lld:pubmed |
| pubmed-article:9920291 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:meshHeading | pubmed-meshheading:9920291-... | lld:pubmed |
| pubmed-article:9920291 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9920291 | pubmed:articleTitle | Inhibition by tetanus toxin of sodium-dependent, high-affinity [3H]5-hydroxytryptamine uptake in rat synaptosomes. | lld:pubmed |
| pubmed-article:9920291 | pubmed:affiliation | Department de Bioquímica i de Biologia Molecular, Facultat de Medicina, Universitat Autonoma de Barcelona, Bellaterra, Spain. | lld:pubmed |
| pubmed-article:9920291 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9920291 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9920291 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9920291 | lld:pubmed |
