| pubmed-article:9918936 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9918936 | lifeskim:mentions | umls-concept:C0019171 | lld:lifeskim |
| pubmed-article:9918936 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:9918936 | lifeskim:mentions | umls-concept:C0160390 | lld:lifeskim |
| pubmed-article:9918936 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:9918936 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:9918936 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9918936 | pubmed:dateCreated | 1999-2-16 | lld:pubmed |
| pubmed-article:9918936 | pubmed:abstractText | A variant avian hepadnavirus that has been shown to destroy hepatocytes in vitro was found to be cytopathic in vivo. A single amino acid change of glycine to glutamic acid at position 133 (G133E) in the preS protein of duck hepatitis B virus (DHBV) caused an increase in the intranuclear pool of viral covalently closed circular DNA (cccDNA), resulting in a transient elevation of viral replication and eventual hepatocyte destruction. In vivo viral infection with the G133E virus was compared with infection with wild-type virus over a 72-day period. Birds were inoculated with virus at day 2 post-hatch to ensure a high percentage of infected hepatocytes and potential persistence of virus. Birds infected with the G133E virus had increased periportal cellular proliferation and numerous lysed apoptotic hepatocytes following 100% infection of hepatocytes. The liver damage within G133E virus-infected birds subsided over time, resulting in mild chronic hepatitis that was similar to that observed within wild-type virus-infected birds. The subsidence of liver damage in G133E virus-infected birds coincided with a reduction of viral cccDNA to wild-type virus levels in the liver. Our study indicates that maintenance of wild-type levels of viral cccDNA promotes persistence of virus infection by establishing a noncytopathic infection. | lld:pubmed |
| pubmed-article:9918936 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9918936 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9918936 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9918936 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9918936 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9918936 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9918936 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9918936 | pubmed:issn | 0270-9139 | lld:pubmed |
| pubmed-article:9918936 | pubmed:author | pubmed-author:SummersJJ | lld:pubmed |
| pubmed-article:9918936 | pubmed:author | pubmed-author:LenhoffR JRJ | lld:pubmed |
| pubmed-article:9918936 | pubmed:author | pubmed-author:LuscombeC ACA | lld:pubmed |
| pubmed-article:9918936 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9918936 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:9918936 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9918936 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9918936 | pubmed:pagination | 563-71 | lld:pubmed |
| pubmed-article:9918936 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9918936 | pubmed:meshHeading | pubmed-meshheading:9918936-... | lld:pubmed |
| pubmed-article:9918936 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9918936 | pubmed:articleTitle | Acute liver injury following infection with a cytopathic strain of duck hepatitis B virus. | lld:pubmed |
| pubmed-article:9918936 | pubmed:affiliation | Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA. | lld:pubmed |
| pubmed-article:9918936 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9918936 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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