Nomenclature for human DPYD alleles.

Source:http://linkedlifedata.com/resource/pubmed/id/9918128

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Authors

van Gennip AH, Johnson MR, Wee T, Diasio RB, Gonzalez FJ, McLeod HL, Vreken P, Sapone A, Fernandez-Salguero P, Collie-Duguid ES, van Kuilenberg AB

Affiliation

Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, UK. h.l.mcleod@abdn.ac.uk

Abstract

To standardize DPYD allele nomenclature and to conform with international human gene nomenclature guidelines, an alternative to the current arbitrary system is described. Based on recommendations for human genome nomenclature, we propose that each distinct allele be designed by DPYD followed by an asterisk and an Arabic numeral. The number specifies the key mutation and, where appropriate, a letter following the number indicates an additional mutation on the mutant allele. Criteria for classification as a distinct allele are also presented.

PMID
9918128