| pubmed-article:9892688 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9892688 | lifeskim:mentions | umls-concept:C1167395 | lld:lifeskim |
| pubmed-article:9892688 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:9892688 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:9892688 | lifeskim:mentions | umls-concept:C0057256 | lld:lifeskim |
| pubmed-article:9892688 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:9892688 | lifeskim:mentions | umls-concept:C0439661 | lld:lifeskim |
| pubmed-article:9892688 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9892688 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:9892688 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9892688 | pubmed:dateCreated | 1999-3-16 | lld:pubmed |
| pubmed-article:9892688 | pubmed:abstractText | Human neutrophil peptide (HNP) defensins were studied to determine their potential effects on adaptive mucosal immunity. Intranasal delivery of HNPs plus ovalbumin (OVA) enhanced OVA-specific serum IgG antibody (Ab) responses. However, OVA-specific IgA Abs were not induced in mucosal secretions or in serum. CD4(+) T cells of intranasally immunized mice displayed higher OVA-specific proliferative responses and elevated production of interferon gamma, interleukin (IL) 5, IL-6, and IL-10 when compared with control groups receiving OVA alone. In vitro, HNPs also enhanced both proliferative responses and T helper (Th) cytokine secretion profiles of CD3epsilon-stimulated spleen- and Peyer's patch-derived naive CD4(+) T cells. HNPs modulated the expression of costimulatory molecules by lipopolysaccharide- or CD3epsilon-stimulated splenic and Peyer's patch B or T cell populations, respectively. These studies show that defensins enhance systemic IgG, but not IgA, Ab responses through help provided by CD4(+) Th1- and Th2-type cytokines and foster B and T cell interactions to link innate immunity with the adaptive immune system. | lld:pubmed |
| pubmed-article:9892688 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9892688 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9892688 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892688 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9892688 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9892688 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:9892688 | pubmed:author | pubmed-author:OppenheimJ... | lld:pubmed |
| pubmed-article:9892688 | pubmed:author | pubmed-author:McGheeJ RJR | lld:pubmed |
| pubmed-article:9892688 | pubmed:author | pubmed-author:BoyakaP NPN | lld:pubmed |
| pubmed-article:9892688 | pubmed:author | pubmed-author:LillardJ... | lld:pubmed |
| pubmed-article:9892688 | pubmed:author | pubmed-author:ChertovOO | lld:pubmed |
| pubmed-article:9892688 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9892688 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:9892688 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:9892688 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9892688 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9892688 | pubmed:pagination | 651-6 | lld:pubmed |
| pubmed-article:9892688 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9892688 | pubmed:meshHeading | pubmed-meshheading:9892688-... | lld:pubmed |
| pubmed-article:9892688 | pubmed:meshHeading | pubmed-meshheading:9892688-... | lld:pubmed |
| pubmed-article:9892688 | pubmed:meshHeading | pubmed-meshheading:9892688-... | lld:pubmed |
| pubmed-article:9892688 | pubmed:meshHeading | pubmed-meshheading:9892688-... | lld:pubmed |
| pubmed-article:9892688 | pubmed:meshHeading | pubmed-meshheading:9892688-... | lld:pubmed |
| pubmed-article:9892688 | pubmed:meshHeading | pubmed-meshheading:9892688-... | lld:pubmed |
| pubmed-article:9892688 | pubmed:meshHeading | pubmed-meshheading:9892688-... | lld:pubmed |
| pubmed-article:9892688 | pubmed:meshHeading | pubmed-meshheading:9892688-... | lld:pubmed |
| pubmed-article:9892688 | pubmed:meshHeading | pubmed-meshheading:9892688-... | lld:pubmed |
| pubmed-article:9892688 | pubmed:meshHeading | pubmed-meshheading:9892688-... | lld:pubmed |
| pubmed-article:9892688 | pubmed:meshHeading | pubmed-meshheading:9892688-... | lld:pubmed |
| pubmed-article:9892688 | pubmed:meshHeading | pubmed-meshheading:9892688-... | lld:pubmed |
| pubmed-article:9892688 | pubmed:meshHeading | pubmed-meshheading:9892688-... | lld:pubmed |
| pubmed-article:9892688 | pubmed:meshHeading | pubmed-meshheading:9892688-... | lld:pubmed |
| pubmed-article:9892688 | pubmed:meshHeading | pubmed-meshheading:9892688-... | lld:pubmed |
