| pubmed-article:9892618 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9892618 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9892618 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:9892618 | lifeskim:mentions | umls-concept:C0242943 | lld:lifeskim |
| pubmed-article:9892618 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:9892618 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:9892618 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9892618 | pubmed:dateCreated | 1999-2-23 | lld:pubmed |
| pubmed-article:9892618 | pubmed:abstractText | The T cell receptor (TCR), from a xeno-reactive murine cytotoxic T lymphocyte clone AHIII12.2, recognizes murine H-2Db complexed with peptide p1027 (FAPGVFPYM), as well as human HLA-A2.1 complexed with peptide p1049 (ALWGFFPVL). A commonly proposed model (the molecular mimicry model) used to explain TCR cross-reactivity suggests that the molecular surfaces of the recognized complexes are similar in shape, charge, or both, in spite of the primary sequence differences. To examine the mechanism of xeno-reactivity of AHIII12.2, we have determined the crystal structures of A2/p1049 and Db/p1027 to 2.5 A and 2.8 A resolution, respectively. The crystal structures show that the TCR footprint regions of the two class I complexes are significantly different in shape and charge. We propose that rather than simple molecular mimicry, unpredictable arrays of common and differential contacts on the two class I complexes are used for their recognition by the same TCR. | lld:pubmed |
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| pubmed-article:9892618 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9892618 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9892618 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9892618 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9892618 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9892618 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:9892618 | pubmed:author | pubmed-author:AppellaEE | lld:pubmed |
| pubmed-article:9892618 | pubmed:author | pubmed-author:CollinsE JEJ | lld:pubmed |
| pubmed-article:9892618 | pubmed:author | pubmed-author:ZhaoRR | lld:pubmed |
| pubmed-article:9892618 | pubmed:author | pubmed-author:LoftusD JDJ | lld:pubmed |
| pubmed-article:9892618 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9892618 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:9892618 | pubmed:volume | 189 | lld:pubmed |
| pubmed-article:9892618 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9892618 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9892618 | pubmed:pagination | 359-70 | lld:pubmed |
| pubmed-article:9892618 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9892618 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9892618 | pubmed:articleTitle | Structural evidence of T cell xeno-reactivity in the absence of molecular mimicry. | lld:pubmed |
| pubmed-article:9892618 | pubmed:affiliation | Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. | lld:pubmed |
| pubmed-article:9892618 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9892618 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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