| pubmed-article:9886567 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9886567 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:9886567 | lifeskim:mentions | umls-concept:C1302401 | lld:lifeskim |
| pubmed-article:9886567 | lifeskim:mentions | umls-concept:C0039676 | lld:lifeskim |
| pubmed-article:9886567 | lifeskim:mentions | umls-concept:C0066357 | lld:lifeskim |
| pubmed-article:9886567 | lifeskim:mentions | umls-concept:C0678951 | lld:lifeskim |
| pubmed-article:9886567 | lifeskim:mentions | umls-concept:C0033522 | lld:lifeskim |
| pubmed-article:9886567 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9886567 | pubmed:dateCreated | 1999-1-21 | lld:pubmed |
| pubmed-article:9886567 | pubmed:abstractText | We examined the relationship between a functional polymorphism (667C-->T, ala-->val) of the methylenetetrahydrofolate reductase gene (MTHFR) and the risk of colorectal adenomas in the prospective Nurses' Health Study. Among 257 incident polyp cases and 713 controls, the MTHFR val/val polymorphism [relative risk (RR) = 1.35, 95% confidence interval (CI) 0.84-2.17] was not significantly associated with risk of adenomas. This lack of association was observed for both small (RR = 1.36, 95% CI 0.76-2.45) and large (RR = 1.32, 95% CI 0.66-2.66) adenomas. Furthermore, there was no significant interaction between this polymorphism and consumption of either folate, methionine or alcohol. We also examined the relationship of a newly identified polymorphism (asp919gly) of the methionine synthase gene (MS) with the risk of colorectal adenomas in the same population. The MS gly/gly polymorphism was also not significantly associated with risk of colorectal adenomas (RR = 0.66, 95% CI 0.26-1.70). These results, which need to be confirmed in other studies, suggest that the MTHFR val/val polymorphism, which has been previously inversely associated with risk of colorectal cancer, plays a role only in a late stage (adenoma-->carcinoma) of colorectal tumorigenesis, and/or may protect against malignant transformation in the subset of benign adenomas, which may progress to malignancy. | lld:pubmed |
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| pubmed-article:9886567 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9886567 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9886567 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9886567 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9886567 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9886567 | pubmed:issn | 0143-3334 | lld:pubmed |
| pubmed-article:9886567 | pubmed:author | pubmed-author:NIEE | lld:pubmed |
| pubmed-article:9886567 | pubmed:author | pubmed-author:ChenJJ | lld:pubmed |
| pubmed-article:9886567 | pubmed:author | pubmed-author:HunterD JDJ | lld:pubmed |
| pubmed-article:9886567 | pubmed:author | pubmed-author:WillettW CWC | lld:pubmed |
| pubmed-article:9886567 | pubmed:author | pubmed-author:KelseyK TKT | lld:pubmed |
| pubmed-article:9886567 | pubmed:author | pubmed-author:GiovannucciEE | lld:pubmed |
| pubmed-article:9886567 | pubmed:author | pubmed-author:SpiegelmanDD | lld:pubmed |
| pubmed-article:9886567 | pubmed:author | pubmed-author:HankinsonS... | lld:pubmed |
| pubmed-article:9886567 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9886567 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:9886567 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9886567 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9886567 | pubmed:pagination | 2129-32 | lld:pubmed |
| pubmed-article:9886567 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9886567 | pubmed:meshHeading | pubmed-meshheading:9886567-... | lld:pubmed |
| pubmed-article:9886567 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9886567 | pubmed:articleTitle | A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma. | lld:pubmed |
| pubmed-article:9886567 | pubmed:affiliation | Department of Epidemiology, Harvard School of Public Health, Brigham and Woman's Hospital, Harvard Medical School, Boston, MA 02115, USA. jia.chen@mountsinai.org | lld:pubmed |
| pubmed-article:9886567 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9886567 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9886567 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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