| pubmed-article:9884158 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9884158 | lifeskim:mentions | umls-concept:C0001973 | lld:lifeskim |
| pubmed-article:9884158 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9884158 | lifeskim:mentions | umls-concept:C0066908 | lld:lifeskim |
| pubmed-article:9884158 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:9884158 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:9884158 | pubmed:dateCreated | 1999-3-29 | lld:pubmed |
| pubmed-article:9884158 | pubmed:abstractText | Mu-Opioid receptor-mediated neurotransmission is involved in the reward, tolerance, and withdrawal effects of alcohol. The present association study tested the hypothesis that the common Asn40Asp substitution polymorphism in the N-terminal domain of the human mu-opioid receptor (OPRM) confers vulnerability to subtypes of alcohol dependence. The genotypes of the Asn40Asp substitution polymorphism were assessed in 327 German alcohol-dependent subjects (according to ICD-10) and in 340 control subjects of German descent, using an assay based on allele-specific polymerase chain reaction. To select alcoholics with a presumed high genetic load, three subgroups were delineated, marked by (1) a family history of parental alcoholism (n = 114); (2) the inability to abstain from alcohol before the age of 26 years (n = 73); and (3) a history of alcohol withdrawal seizure or delirium (n = 107). The frequency of the Asp40 allele did not differ significantly between the controls [f(Asp40) = 0.078] and either the entire group of alcoholics [f(Asp40) = 0.107; p = 0.066], or the alcoholics with parental alcoholism [f(Asp40) = 0.114; p = 0.094], or the early-onset alcoholics [f(Asp40) = 0.096; p = 0.471,[ or the alcoholics with severe withdrawal symptoms [f(Asp40) = 0.098; p = 0.350]. Our results do not provide evidence that the common Asn40Asp substitution polymorphism of the OPRM gene contributes a major effect to the pathogenesis of alcohol dependence. | lld:pubmed |
| pubmed-article:9884158 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9884158 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9884158 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9884158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9884158 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9884158 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9884158 | pubmed:issn | 0145-6008 | lld:pubmed |
| pubmed-article:9884158 | pubmed:author | pubmed-author:SchmidtL GLG | lld:pubmed |
| pubmed-article:9884158 | pubmed:author | pubmed-author:Rommelspacher... | lld:pubmed |
| pubmed-article:9884158 | pubmed:author | pubmed-author:HoeheM RMR | lld:pubmed |
| pubmed-article:9884158 | pubmed:author | pubmed-author:SanderTT | lld:pubmed |
| pubmed-article:9884158 | pubmed:author | pubmed-author:SmolkaMM | lld:pubmed |
| pubmed-article:9884158 | pubmed:author | pubmed-author:SamochowiecJJ | lld:pubmed |
| pubmed-article:9884158 | pubmed:author | pubmed-author:WendelBB | lld:pubmed |
| pubmed-article:9884158 | pubmed:author | pubmed-author:GscheidelNN | lld:pubmed |
| pubmed-article:9884158 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9884158 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:9884158 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9884158 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9884158 | pubmed:pagination | 2108-10 | lld:pubmed |
| pubmed-article:9884158 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9884158 | pubmed:meshHeading | pubmed-meshheading:9884158-... | lld:pubmed |
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| pubmed-article:9884158 | pubmed:meshHeading | pubmed-meshheading:9884158-... | lld:pubmed |
| pubmed-article:9884158 | pubmed:meshHeading | pubmed-meshheading:9884158-... | lld:pubmed |
| pubmed-article:9884158 | pubmed:meshHeading | pubmed-meshheading:9884158-... | lld:pubmed |
| pubmed-article:9884158 | pubmed:meshHeading | pubmed-meshheading:9884158-... | lld:pubmed |
| pubmed-article:9884158 | pubmed:meshHeading | pubmed-meshheading:9884158-... | lld:pubmed |
| pubmed-article:9884158 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9884158 | pubmed:articleTitle | Human mu-opioid receptor variation and alcohol dependence. | lld:pubmed |
| pubmed-article:9884158 | pubmed:affiliation | Department of Psychiatry, University Hospital Benjamin Franklin, Free University of Berlin, Germany. | lld:pubmed |
| pubmed-article:9884158 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9884158 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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