pubmed-article:9882347 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9882347 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
pubmed-article:9882347 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
pubmed-article:9882347 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
pubmed-article:9882347 | lifeskim:mentions | umls-concept:C1709694 | lld:lifeskim |
pubmed-article:9882347 | lifeskim:mentions | umls-concept:C1611645 | lld:lifeskim |
pubmed-article:9882347 | lifeskim:mentions | umls-concept:C0676910 | lld:lifeskim |
pubmed-article:9882347 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:9882347 | pubmed:dateCreated | 1999-2-18 | lld:pubmed |
pubmed-article:9882347 | pubmed:abstractText | Proteolytic processing is required for the activation of numerous viral glycoproteins. Here we show that the envelope glycoprotein from the Zaire strain of Ebola virus (Ebo-GP) is proteolytically processed into two subunits, GP1 and GP2, that are likely covalently associated through a disulfide linkage. Murine leukemia virions pseudotyped with Ebo-GP contain almost exclusively processed glycoprotein, indicating that this is the mature form of Ebo-GP. Mutational analysis identified a dibasic motif, reminiscent of furin-like protease processing sites, as the Ebo-GP cleavage site. However, analysis of Ebo-GP processing in LoVo cells that lack the proprotein convertase furin demonstrated that furin is not required for processing of Ebo-GP. In sharp contrast to other viral systems, we found that an uncleaved mutant of Ebo-GP was able to mediate infection of various cell lines as efficiently as the wild-type, proteolytically cleaved glycoprotein, indicating that cleavage is not required for the activation of Ebo-GP despite the conservation of a dibasic cleavage site in all filoviral envelope glycoproteins. | lld:pubmed |
pubmed-article:9882347 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:language | eng | lld:pubmed |
pubmed-article:9882347 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:9882347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9882347 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9882347 | pubmed:month | Feb | lld:pubmed |
pubmed-article:9882347 | pubmed:issn | 0022-538X | lld:pubmed |
pubmed-article:9882347 | pubmed:author | pubmed-author:BatesPP | lld:pubmed |
pubmed-article:9882347 | pubmed:author | pubmed-author:Wool-LewisR... | lld:pubmed |
pubmed-article:9882347 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9882347 | pubmed:volume | 73 | lld:pubmed |
pubmed-article:9882347 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9882347 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9882347 | pubmed:pagination | 1419-26 | lld:pubmed |
pubmed-article:9882347 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:meshHeading | pubmed-meshheading:9882347-... | lld:pubmed |
pubmed-article:9882347 | pubmed:year | 1999 | lld:pubmed |
pubmed-article:9882347 | pubmed:articleTitle | Endoproteolytic processing of the ebola virus envelope glycoprotein: cleavage is not required for function. | lld:pubmed |