| pubmed-article:9881976 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9881976 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:9881976 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:9881976 | lifeskim:mentions | umls-concept:C0877857 | lld:lifeskim |
| pubmed-article:9881976 | lifeskim:mentions | umls-concept:C0439742 | lld:lifeskim |
| pubmed-article:9881976 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:9881976 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:9881976 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:9881976 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:9881976 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:9881976 | pubmed:dateCreated | 1999-1-28 | lld:pubmed |
| pubmed-article:9881976 | pubmed:abstractText | Searching for an in vitro model for somatic hypermutation, we have identified an IgM-expressing Burkitt lymphoma line that constitutively diversifies its immunoglobulin V domain at high rate during culture. As in in vivo, the mutations are largely nucleotide substitutions with the pattern of substitutions revealing a component of the human hypermutation program that is preferentially targeted to G/C residues. The substitutions frequently create stop codons with IgM-loss variants also being generated by V domain-specific deletions and duplications. However, in transfectants expressing terminal deoxynucleotidyl transferase, many IgM-loss variants additionally arise through short nontemplated nucleotide insertions into the V (but not C) domain. Thus, antibody hypermutation is likely accompanied by DNA strand breaks scattered within the mutation domain. | lld:pubmed |
| pubmed-article:9881976 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9881976 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9881976 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9881976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9881976 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9881976 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9881976 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:9881976 | pubmed:author | pubmed-author:NeubergerM... | lld:pubmed |
| pubmed-article:9881976 | pubmed:author | pubmed-author:SHIHC YCY | lld:pubmed |
| pubmed-article:9881976 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9881976 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:9881976 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9881976 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9881976 | pubmed:pagination | 859-69 | lld:pubmed |
| pubmed-article:9881976 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:9881976 | pubmed:meshHeading | pubmed-meshheading:9881976-... | lld:pubmed |
| pubmed-article:9881976 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9881976 | pubmed:articleTitle | TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. | lld:pubmed |
| pubmed-article:9881976 | pubmed:affiliation | Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom. | lld:pubmed |
| pubmed-article:9881976 | pubmed:publicationType | Journal Article | lld:pubmed |
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