pubmed-article:9881970 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9881970 | lifeskim:mentions | umls-concept:C0242299 | lld:lifeskim |
pubmed-article:9881970 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
pubmed-article:9881970 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
pubmed-article:9881970 | lifeskim:mentions | umls-concept:C0253023 | lld:lifeskim |
pubmed-article:9881970 | lifeskim:mentions | umls-concept:C0597298 | lld:lifeskim |
pubmed-article:9881970 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:9881970 | lifeskim:mentions | umls-concept:C1819447 | lld:lifeskim |
pubmed-article:9881970 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
pubmed-article:9881970 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
pubmed-article:9881970 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
pubmed-article:9881970 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:9881970 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:9881970 | pubmed:issue | 6 | lld:pubmed |
pubmed-article:9881970 | pubmed:dateCreated | 1999-1-28 | lld:pubmed |
pubmed-article:9881970 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9881970 | pubmed:abstractText | We have identified RORgamma t, a novel, thymus-specific isoform of the orphan nuclear receptor RORgamma that is expressed predominantly in CD4+ CD8+ double-positive thymocytes. Ectopic expression of RORgamma t protects T cell hybridomas from activation-induced cell death by inhibiting the upregulation of Fas ligand. Following hybridoma stimulation, RORgamma t also inhibits IL-2 production but does not affect the induction of Nur-77 and Egr-3 nor the upregulation of CD69. Both the ligand-binding and DNA-binding domains of RORgamma t are required for this effect. We propose that the role of RORgamma t expression in immature thymocytes is to inhibit Fas ligand expression and cytokine secretion following engagement of their TCR during positive or negative selection. | lld:pubmed |
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pubmed-article:9881970 | pubmed:language | eng | lld:pubmed |
pubmed-article:9881970 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9881970 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:9881970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9881970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9881970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9881970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9881970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9881970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9881970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9881970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9881970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9881970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9881970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9881970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9881970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9881970 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9881970 | pubmed:month | Dec | lld:pubmed |
pubmed-article:9881970 | pubmed:issn | 1074-7613 | lld:pubmed |
pubmed-article:9881970 | pubmed:author | pubmed-author:BevanM JMJ | lld:pubmed |