| pubmed-article:9877394 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9877394 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:9877394 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:9877394 | lifeskim:mentions | umls-concept:C0013878 | lld:lifeskim |
| pubmed-article:9877394 | lifeskim:mentions | umls-concept:C0003209 | lld:lifeskim |
| pubmed-article:9877394 | lifeskim:mentions | umls-concept:C0040302 | lld:lifeskim |
| pubmed-article:9877394 | lifeskim:mentions | umls-concept:C1155099 | lld:lifeskim |
| pubmed-article:9877394 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:9877394 | lifeskim:mentions | umls-concept:C1514829 | lld:lifeskim |
| pubmed-article:9877394 | lifeskim:mentions | umls-concept:C1515999 | lld:lifeskim |
| pubmed-article:9877394 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:9877394 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:9877394 | pubmed:dateCreated | 1999-1-14 | lld:pubmed |
| pubmed-article:9877394 | pubmed:abstractText | The anti-inflammatory mediator interleukin-10 was investigated as a potential inhibitor of proinflammatory cytokine release in human peripheral blood monocytes activated with titanium particles. It inhibited the secretion of both tumor necrosis factor-alpha and interleukin-6 in a dose-dependent manner, with complete inhibition observed at 2 ng/ml. Co-culture experiments were performed to determine whether this cytokine may have functional importance as an inhibitor of the inflammatory response. When unstimulated lymphocytes and monocytes were co-cultured with titanium-stimulated monocytes, they significantly suppressed the secretion of both interleukin-6 and tumor necrosis factor-alpha. The inhibitory effect of these co-cultured cells could be partially blocked with the addition of an interleukin-10 neutralizing antibody. Interleukin-10 levels were measured in monocyte cultures treated with titanium particles as well as in fresh monocyte cultures treated with conditioned medium from titanium-stimulated monocytes. The latter experiments demonstrated marked stimulation of interleukin-10 secretion in conditioned medium-treated cultures, an effect that was related to the presence of tumor necrosis factor-alpha in the conditioned medium. The addition of titanium to conditioned medium-treated cultures markedly reduced the secretion of interleukin-10, suggesting that the most responsive cells are unstimulated monocytes exposed to agents released from activated monocytes. Altogether, the expression and responsiveness to interleukin-10 suggest a potential role for anti-inflammatory cytokines in regulation of the inflammatory response to wear debris. | lld:pubmed |
| pubmed-article:9877394 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9877394 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9877394 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9877394 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9877394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9877394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9877394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9877394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9877394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9877394 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9877394 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9877394 | pubmed:issn | 0736-0266 | lld:pubmed |
| pubmed-article:9877394 | pubmed:author | pubmed-author:PuzasJ EJE | lld:pubmed |
| pubmed-article:9877394 | pubmed:author | pubmed-author:HsuJJ | lld:pubmed |
| pubmed-article:9877394 | pubmed:author | pubmed-author:RosierR NRN | lld:pubmed |
| pubmed-article:9877394 | pubmed:author | pubmed-author:O'KeefeR JRJ | lld:pubmed |
| pubmed-article:9877394 | pubmed:author | pubmed-author:HicksD GDG | lld:pubmed |
| pubmed-article:9877394 | pubmed:author | pubmed-author:ReynoldsP RPR | lld:pubmed |
| pubmed-article:9877394 | pubmed:author | pubmed-author:PolliceP FPF | lld:pubmed |
| pubmed-article:9877394 | pubmed:author | pubmed-author:BukataSS | lld:pubmed |
| pubmed-article:9877394 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9877394 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:9877394 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9877394 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9877394 | pubmed:pagination | 697-704 | lld:pubmed |
| pubmed-article:9877394 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9877394 | pubmed:meshHeading | pubmed-meshheading:9877394-... | lld:pubmed |
| pubmed-article:9877394 | pubmed:meshHeading | pubmed-meshheading:9877394-... | lld:pubmed |
| pubmed-article:9877394 | pubmed:meshHeading | pubmed-meshheading:9877394-... | lld:pubmed |
| pubmed-article:9877394 | pubmed:meshHeading | pubmed-meshheading:9877394-... | lld:pubmed |
| pubmed-article:9877394 | pubmed:meshHeading | pubmed-meshheading:9877394-... | lld:pubmed |
| pubmed-article:9877394 | pubmed:meshHeading | pubmed-meshheading:9877394-... | lld:pubmed |
| pubmed-article:9877394 | pubmed:meshHeading | pubmed-meshheading:9877394-... | lld:pubmed |
| pubmed-article:9877394 | pubmed:meshHeading | pubmed-meshheading:9877394-... | lld:pubmed |
| pubmed-article:9877394 | pubmed:meshHeading | pubmed-meshheading:9877394-... | lld:pubmed |
| pubmed-article:9877394 | pubmed:meshHeading | pubmed-meshheading:9877394-... | lld:pubmed |
| pubmed-article:9877394 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9877394 | pubmed:articleTitle | Interleukin-10 inhibits cytokine synthesis in monocytes stimulated by titanium particles: evidence of an anti-inflammatory regulatory pathway. | lld:pubmed |
| pubmed-article:9877394 | pubmed:affiliation | Department of Orthopaedics, University of Rochester School of Medicine and Dentistry, New York 14642, USA. | lld:pubmed |
| pubmed-article:9877394 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9877394 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9877394 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
