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pubmed-article:9875537pubmed:abstractTextMany studies show that monoamine oxidase B in blood cells is a biological marker for personality characteristics such as sensation seeking. The mechanism underlying this association is so far not explored. In the present study we have performed electrophoretic mobility-shift assays to investigate the pattern of protein binding to a 150 bp fragment of the proximal 5'-flanking region of the human monoamine oxidase B gene. We compared the pattern using nuclear extracts from human brain and lymphocytes. Interestingly, a correlation was observed between monoamine oxidase B enzyme activity in blood cells (platelets) and the binding pattern of two uncharacterized transcription factors. These data are well in line with the long-standing notion that interindividual differences in platelet monoamine oxidase may represent differences in expression of the enzyme rather than genotypic variation.lld:pubmed
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pubmed-article:9875537pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:9875537pubmed:articleTitleTranscription factor binding to the core promoter of the human monoamine oxidase B gene in the cerebral cortex and in blood cells.lld:pubmed
pubmed-article:9875537pubmed:affiliationDepartment of Neuroscience, Uppsala University, Sweden.lld:pubmed
pubmed-article:9875537pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9875537pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed