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pubmed-article:9873731pubmed:abstractTextA series of lysosomal protease-sensitive peptides attached to doxorubicin (DOX) was prepared as model substrates for internalizing anticancer immunoconjugates and potential antimetastasis prodrugs. Rates of cathepsin B-mediated release of free drug was measured for each, and human plasma stabilities for representative examples.lld:pubmed
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pubmed-article:9873731pubmed:articleTitleCathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin.lld:pubmed
pubmed-article:9873731pubmed:affiliationBristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492-7660, USA.lld:pubmed
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