| pubmed-article:9873636 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9873636 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:9873636 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:9873636 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:9873636 | lifeskim:mentions | umls-concept:C0082338 | lld:lifeskim |
| pubmed-article:9873636 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:9873636 | lifeskim:mentions | umls-concept:C0439596 | lld:lifeskim |
| pubmed-article:9873636 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:9873636 | pubmed:dateCreated | 1999-2-2 | lld:pubmed |
| pubmed-article:9873636 | pubmed:abstractText | A cyclic analog of the natural antiproliferative compound dolastatin 10 was synthesized by introducing an ester link between the N- and C-terminal residues which were modified accordingly. The final macrolactonization was performed by using isopropenyl chloroformate and DMAP as reagents. This analog exhibits submicromolar antiproliferative activity against the L1210 and HT29 cell lines and inhibits in vitro tubulin polymerization (IC50, 39 microM). | lld:pubmed |
| pubmed-article:9873636 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9873636 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9873636 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9873636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9873636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9873636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9873636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9873636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9873636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9873636 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9873636 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9873636 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:9873636 | pubmed:author | pubmed-author:PierréAA | lld:pubmed |
| pubmed-article:9873636 | pubmed:author | pubmed-author:AtassiGG | lld:pubmed |
| pubmed-article:9873636 | pubmed:author | pubmed-author:JouinPP | lld:pubmed |
| pubmed-article:9873636 | pubmed:author | pubmed-author:Guéritte-Voeg... | lld:pubmed |
| pubmed-article:9873636 | pubmed:author | pubmed-author:PoncetJJ | lld:pubmed |
| pubmed-article:9873636 | pubmed:author | pubmed-author:BusquetMM | lld:pubmed |
| pubmed-article:9873636 | pubmed:author | pubmed-author:ThoretSS | lld:pubmed |
| pubmed-article:9873636 | pubmed:author | pubmed-author:HortalaLL | lld:pubmed |
| pubmed-article:9873636 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9873636 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:9873636 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:9873636 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9873636 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9873636 | pubmed:pagination | 2855-8 | lld:pubmed |
| pubmed-article:9873636 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9873636 | pubmed:meshHeading | pubmed-meshheading:9873636-... | lld:pubmed |
| pubmed-article:9873636 | pubmed:meshHeading | pubmed-meshheading:9873636-... | lld:pubmed |
| pubmed-article:9873636 | pubmed:meshHeading | pubmed-meshheading:9873636-... | lld:pubmed |
| pubmed-article:9873636 | pubmed:meshHeading | pubmed-meshheading:9873636-... | lld:pubmed |
| pubmed-article:9873636 | pubmed:meshHeading | pubmed-meshheading:9873636-... | lld:pubmed |
| pubmed-article:9873636 | pubmed:meshHeading | pubmed-meshheading:9873636-... | lld:pubmed |
| pubmed-article:9873636 | pubmed:meshHeading | pubmed-meshheading:9873636-... | lld:pubmed |
| pubmed-article:9873636 | pubmed:meshHeading | pubmed-meshheading:9873636-... | lld:pubmed |
| pubmed-article:9873636 | pubmed:meshHeading | pubmed-meshheading:9873636-... | lld:pubmed |
| pubmed-article:9873636 | pubmed:meshHeading | pubmed-meshheading:9873636-... | lld:pubmed |
| pubmed-article:9873636 | pubmed:meshHeading | pubmed-meshheading:9873636-... | lld:pubmed |
| pubmed-article:9873636 | pubmed:meshHeading | pubmed-meshheading:9873636-... | lld:pubmed |
| pubmed-article:9873636 | pubmed:meshHeading | pubmed-meshheading:9873636-... | lld:pubmed |
| pubmed-article:9873636 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9873636 | pubmed:articleTitle | Synthesis and antiproliferative activity of a cyclic analog of dolastatin 10. | lld:pubmed |
| pubmed-article:9873636 | pubmed:affiliation | Laboratoire des Mécanismes Moléculaires des Communications Cellulaires (CNRS UPR 9023), Montpellier, France. poncet@ccipe.montp.inserm.fr | lld:pubmed |
| pubmed-article:9873636 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:9873636 | lld:chembl |
