| pubmed-article:9873633 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9873633 | lifeskim:mentions | umls-concept:C0010546 | lld:lifeskim |
| pubmed-article:9873633 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:9873633 | lifeskim:mentions | umls-concept:C0007996 | lld:lifeskim |
| pubmed-article:9873633 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
| pubmed-article:9873633 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:9873633 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:9873633 | lifeskim:mentions | umls-concept:C2347168 | lld:lifeskim |
| pubmed-article:9873633 | lifeskim:mentions | umls-concept:C0755562 | lld:lifeskim |
| pubmed-article:9873633 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:9873633 | pubmed:dateCreated | 1999-2-2 | lld:pubmed |
| pubmed-article:9873633 | pubmed:abstractText | In search of antiinflammatory drugs with a new mechanism of action, U0126 was found to functionally antagonize AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase MEK with an IC50 of 0.07 microM for MEK 1 and 0.06 microM for MEK 2. U0126 can undergo isomerization and cyclization reactions to form a variety of products, both chemically and in vivo, all of which exhibit less affinity for MEK and lower inhibition of AP-1 activity than parent, U0126. | lld:pubmed |
| pubmed-article:9873633 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9873633 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9873633 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9873633 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9873633 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:HoriuchiKK | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:MagoldaR LRL | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:OlsonR ERE | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:SueJ SJS | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:CopelandR ARA | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:EarlR ARA | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:MartzR CRC | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:BlomK FKF | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:DunciaJ VJV | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:WexlerR RRR | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:HobbsF WFW | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:ScherleP APA | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:TrainorG LGL | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:SantellaJ... | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:TrzaskosJ MJM | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:FavataM FMF | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:PittsW JWJ | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:HigleyC ACA | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:DaulerioA JAJ | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:WityakJJ | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:RankinF WFW | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:FrietzeW EWE | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:StradleyD ADA | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:TelehaC ACA | lld:pubmed |
| pubmed-article:9873633 | pubmed:author | pubmed-author:TabakaA CAC | lld:pubmed |
| pubmed-article:9873633 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9873633 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:9873633 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:9873633 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9873633 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9873633 | pubmed:pagination | 2839-44 | lld:pubmed |
| pubmed-article:9873633 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:9873633 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9873633 | pubmed:articleTitle | MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. | lld:pubmed |
| pubmed-article:9873633 | pubmed:affiliation | DuPont Pharmaceuticals Company, Chemical and Physical Sciences Department, Wilmington, DE 19880, USA. | lld:pubmed |
| pubmed-article:9873633 | pubmed:publicationType | Journal Article | lld:pubmed |
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