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pubmed-article:9873567pubmed:abstractTextEarly T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56lck, is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56lck.lld:pubmed
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pubmed-article:9873567pubmed:articleTitleThe development of novel and selective p56lck tyrosine kinase inhibitors.lld:pubmed
pubmed-article:9873567pubmed:affiliationR. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.lld:pubmed
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