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pubmed-article:9873566pubmed:abstractTextA QSAR study using the novel hydrophobic descriptor (logPmw), which is a descriptor for membrane affinity, of our fibrinogen inhibitors FK633 (1), FR158999 (21), and related derivatives was performed, and resulted in good correlation (n = 19, s = 0.268, F = 6.38**, r = 0.667). Based on these results, we constructed a hypothesis by which these potent inhibitors bind to the receptor via the biomembrane and the C-terminal moiety functions as an anchor moiety.lld:pubmed
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pubmed-article:9873566pubmed:articleTitleQSAR study of the peptidic fibrinogen inhibitors FK633, FR158999 and related derivatives, using a novel and useful hydrophobic descriptor (logPmw).lld:pubmed
pubmed-article:9873566pubmed:affiliationBasic Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Osaka, Japan.lld:pubmed
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