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pubmed-article:9873504pubmed:abstractTextFour isomeric methyl substituted DCK analogues (2-5) were asymmetrically synthesized from different starting materials. 3-Methyl, 4-methyl, and 5-methyl-3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (2-4) all were extremely potent against HIV-1 replication in H9 lymphocyte cells with EC50 and therapeutic index values of < 4.23 x 10(-7) microM and > 3.72 x 10(8), respectively, which are much better than those of DCK and AZT in this assay.lld:pubmed
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pubmed-article:9873504pubmed:articleTitleAnti-AIDS agents. 33. Synthesis and anti-HIV activity of mono-methyl substituted 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) analogues.lld:pubmed
pubmed-article:9873504pubmed:affiliationNatural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA.lld:pubmed
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pubmed-article:9873504pubmed:publicationTypeComparative Studylld:pubmed
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