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pubmed-article:9873487pubmed:abstractTextA series of 3-phenylpyrazolo[1,5-a]pyrimidines was prepared and found to have affinity for the human CRF-1 receptor. The 3-dimensional structure of one of the most potent analogs in this series, 10d, was determined by X-ray crystallography and suggests the spatial requirements for potent CRF-1 receptor binding affinity in this series.lld:pubmed
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pubmed-article:9873487pubmed:articleTitlePyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists.lld:pubmed
pubmed-article:9873487pubmed:affiliationParke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105, USA.lld:pubmed
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