| pubmed-article:9871775 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9871775 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:9871775 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:9871775 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:9871775 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:9871775 | lifeskim:mentions | umls-concept:C0596448 | lld:lifeskim |
| pubmed-article:9871775 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:9871775 | pubmed:dateCreated | 1999-3-11 | lld:pubmed |
| pubmed-article:9871775 | pubmed:abstractText | New dimers of known 5HT1 ligands (5HT, 1-NP or 8-OH-DPAT) have been prepared and evaluated at human cloned 5HT1B, 5HT1D and 5HT1A receptors. Binding experiments show that all these dimers have better affinities at 5HT1B/1D receptors than their corresponding monomeric ligands. Studies of inhibition of the forskolin-stimulated c-AMP formation mediated by the human 5HT1B receptor show that hetero-bivalent ligands [combining an agonist (5HT) with an antagonist (1-NP)] behave as partial agonists while the intrinsic activity of bivalent antagonists (combining two 1-NP residues) was found to be spacer dependent. Surprisingly enough, the dimer of 8-OH-DPAT 6 binds to 5HT1A, 5HT1B and 5HT1D receptors with similar high affinity. | lld:pubmed |
| pubmed-article:9871775 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9871775 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871775 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9871775 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871775 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871775 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871775 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871775 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871775 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871775 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871775 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871775 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871775 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871775 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871775 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871775 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871775 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871775 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871775 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9871775 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9871775 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:9871775 | pubmed:author | pubmed-author:PerezMM | lld:pubmed |
| pubmed-article:9871775 | pubmed:author | pubmed-author:PauwelsP JPJ | lld:pubmed |
| pubmed-article:9871775 | pubmed:author | pubmed-author:HalazySS | lld:pubmed |
| pubmed-article:9871775 | pubmed:author | pubmed-author:PallardII | lld:pubmed |
| pubmed-article:9871775 | pubmed:author | pubmed-author:Jorand-Lebrun... | lld:pubmed |
| pubmed-article:9871775 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9871775 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:9871775 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:9871775 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9871775 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9871775 | pubmed:pagination | 1407-12 | lld:pubmed |
| pubmed-article:9871775 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:9871775 | pubmed:meshHeading | pubmed-meshheading:9871775-... | lld:pubmed |
| pubmed-article:9871775 | pubmed:meshHeading | pubmed-meshheading:9871775-... | lld:pubmed |
| pubmed-article:9871775 | pubmed:meshHeading | pubmed-meshheading:9871775-... | lld:pubmed |
| pubmed-article:9871775 | pubmed:meshHeading | pubmed-meshheading:9871775-... | lld:pubmed |
| pubmed-article:9871775 | pubmed:meshHeading | pubmed-meshheading:9871775-... | lld:pubmed |
| pubmed-article:9871775 | pubmed:meshHeading | pubmed-meshheading:9871775-... | lld:pubmed |
| pubmed-article:9871775 | pubmed:meshHeading | pubmed-meshheading:9871775-... | lld:pubmed |
| pubmed-article:9871775 | pubmed:meshHeading | pubmed-meshheading:9871775-... | lld:pubmed |
| pubmed-article:9871775 | pubmed:meshHeading | pubmed-meshheading:9871775-... | lld:pubmed |
| pubmed-article:9871775 | pubmed:meshHeading | pubmed-meshheading:9871775-... | lld:pubmed |
| pubmed-article:9871775 | pubmed:meshHeading | pubmed-meshheading:9871775-... | lld:pubmed |
| pubmed-article:9871775 | pubmed:meshHeading | pubmed-meshheading:9871775-... | lld:pubmed |
| pubmed-article:9871775 | pubmed:meshHeading | pubmed-meshheading:9871775-... | lld:pubmed |
| pubmed-article:9871775 | pubmed:meshHeading | pubmed-meshheading:9871775-... | lld:pubmed |
| pubmed-article:9871775 | pubmed:meshHeading | pubmed-meshheading:9871775-... | lld:pubmed |
| pubmed-article:9871775 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9871775 | pubmed:articleTitle | Dimers of 5HT1 ligands preferentially bind to 5HT1B/1D receptor subtypes. | lld:pubmed |
| pubmed-article:9871775 | pubmed:affiliation | Medicinal Chemistry Division, Centre de Recherche Pierre FABRE, Castres, France. | lld:pubmed |
| pubmed-article:9871775 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:9871775 | lld:chembl |
