| pubmed-article:9871092 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9871092 | lifeskim:mentions | umls-concept:C0001779 | lld:lifeskim |
| pubmed-article:9871092 | lifeskim:mentions | umls-concept:C0079399 | lld:lifeskim |
| pubmed-article:9871092 | lifeskim:mentions | umls-concept:C1708335 | lld:lifeskim |
| pubmed-article:9871092 | lifeskim:mentions | umls-concept:C0289174 | lld:lifeskim |
| pubmed-article:9871092 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:9871092 | lifeskim:mentions | umls-concept:C0040395 | lld:lifeskim |
| pubmed-article:9871092 | lifeskim:mentions | umls-concept:C1613902 | lld:lifeskim |
| pubmed-article:9871092 | lifeskim:mentions | umls-concept:C0233929 | lld:lifeskim |
| pubmed-article:9871092 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9871092 | pubmed:dateCreated | 1999-1-21 | lld:pubmed |
| pubmed-article:9871092 | pubmed:abstractText | 5-HT2A receptors have been implicated in the pathophysiology of mood disorders and in the therapeutic effect of the so-called atypical antipsychotics. Recently, a new radioiodinated ligand with high affinity and selectivity for serotonin 5-HT2A receptors, 123iodinated 4-amino-N-1-[3-(4-fluorophenoxy)propyl]-4-methyl-4-piperidinyl] 5-iodo-2-methoxybenzamide (123I-5-I-R91150), has been developed and has been shown to be suitable for single-photon emission tomography (SPET) imaging. In this study the influence of age and gender on the ligand binding was investigated in normal volunteers. One hundred and fifty MBq of 123I-5-I-R91150 was administered to 26 normal volunteers (13 females and 13 males) with an age range of 23-60 years. SPET imaging was performed with a triple-headed gamma camera. For semi-quantitative analysis, ratios of ligand binding in different regions of interest to the binding in the cerebellum were calculated. Mean ratios of 1.7 were obtained. No gender difference was demonstrated. 5-HT2A binding was shown to decline with age. Over an age range of 40 years a reduction in ligand binding of 42% +/- 7% was found. These results are in agreement w in vitro and positron emission tomography findings of a decline in 5-HT2A receptor binding with age. The findings confirm the suitability of 123I-5-I-R91150 for SPET imaging of 5-HT2A receptors, and highlight the necessity for age-matched controls in clinical studies. | lld:pubmed |
| pubmed-article:9871092 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9871092 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871092 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9871092 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871092 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871092 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871092 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871092 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871092 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9871092 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9871092 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9871092 | pubmed:issn | 0340-6997 | lld:pubmed |
| pubmed-article:9871092 | pubmed:author | pubmed-author:BossuytAA | lld:pubmed |
| pubmed-article:9871092 | pubmed:author | pubmed-author:MertensJJ | lld:pubmed |
| pubmed-article:9871092 | pubmed:author | pubmed-author:D'haenenHH | lld:pubmed |
| pubmed-article:9871092 | pubmed:author | pubmed-author:FlamenPP | lld:pubmed |
| pubmed-article:9871092 | pubmed:author | pubmed-author:TerriereDD | lld:pubmed |
| pubmed-article:9871092 | pubmed:author | pubmed-author:ChavatteKK | lld:pubmed |
| pubmed-article:9871092 | pubmed:author | pubmed-author:BaekenCC | lld:pubmed |
| pubmed-article:9871092 | pubmed:author | pubmed-author:BoumonRR | lld:pubmed |
| pubmed-article:9871092 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9871092 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:9871092 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9871092 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9871092 | pubmed:pagination | 1617-22 | lld:pubmed |
| pubmed-article:9871092 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:9871092 | pubmed:meshHeading | pubmed-meshheading:9871092-... | lld:pubmed |
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| pubmed-article:9871092 | pubmed:meshHeading | pubmed-meshheading:9871092-... | lld:pubmed |
| pubmed-article:9871092 | pubmed:meshHeading | pubmed-meshheading:9871092-... | lld:pubmed |
| pubmed-article:9871092 | pubmed:meshHeading | pubmed-meshheading:9871092-... | lld:pubmed |
| pubmed-article:9871092 | pubmed:meshHeading | pubmed-meshheading:9871092-... | lld:pubmed |
| pubmed-article:9871092 | pubmed:meshHeading | pubmed-meshheading:9871092-... | lld:pubmed |
| pubmed-article:9871092 | pubmed:meshHeading | pubmed-meshheading:9871092-... | lld:pubmed |
| pubmed-article:9871092 | pubmed:meshHeading | pubmed-meshheading:9871092-... | lld:pubmed |
| pubmed-article:9871092 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9871092 | pubmed:articleTitle | 123I-5-I-R91150, a new single-photon emission tomography ligand for 5-HT2A receptors: influence of age and gender in healthy subjects. | lld:pubmed |
| pubmed-article:9871092 | pubmed:affiliation | Department of Psychiatry, Academic Hospital, Brussels, Belgium. | lld:pubmed |
| pubmed-article:9871092 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9871092 | lld:pubmed |
