| pubmed-article:9862743 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9862743 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:9862743 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9862743 | lifeskim:mentions | umls-concept:C0021759 | lld:lifeskim |
| pubmed-article:9862743 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:9862743 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:9862743 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9862743 | pubmed:dateCreated | 1999-1-22 | lld:pubmed |
| pubmed-article:9862743 | pubmed:abstractText | We have used a mouse model of allergen-induced airway hyperresponsiveness to demonstrate that immunostimulatory DNA sequences (ISS) containing a CpG DNA motif significantly inhibit airway eosinophilia and reduce responsiveness to inhaled methacholine. ISS not only inhibited eosinophilia of the airway (by 93%) and lung parenchyma (91%), but also significantly inhibited blood eosinophilia (86%), suggesting that ISS was exerting a significant effect on the bone marrow production of eosinophils. The inhibition of the bone marrow production of eosinophils by 58% was associated with a significant inhibition of T cell-derived cytokine generation (IL-5, granulocyte-macrophage CSF, and IL-3). ISS exerted this inhibitory effect on T cell cytokine production indirectly by stimulating monocytes/macrophages and NK cells to generate IL-12 and IFNs. The onset of the ISS effect on reducing the number of tissue eosinophils was both immediate (within 1 day of administration) and sustained (lasted 6 days), and was not due to ISS directly inducing eosinophil apoptosis. ISS was effective in inhibiting eosinophilic airway inflammation when administered either systemically (i.p.), or mucosally (i.e., intranasally or intratracheally). Interestingly, a single dose of ISS inhibited airway eosinophilia as effectively as daily injections of corticosteroids for 7 days. Moreover, while both ISS and corticosteroids inhibited IL-5 generation, only ISS was able to induce allergen-specific IFN-gamma production and redirect the immune system toward a Th1 response. Thus, systemic or mucosal administration of ISS before allergen exposure could provide a novel form of active immunotherapy in allergic diseases. | lld:pubmed |
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| pubmed-article:9862743 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9862743 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9862743 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9862743 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9862743 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9862743 | pubmed:author | pubmed-author:GelfandE WEW | lld:pubmed |
| pubmed-article:9862743 | pubmed:author | pubmed-author:RaoNN | lld:pubmed |
| pubmed-article:9862743 | pubmed:author | pubmed-author:SchwarzeJJ | lld:pubmed |
| pubmed-article:9862743 | pubmed:author | pubmed-author:BroidaHH | lld:pubmed |
| pubmed-article:9862743 | pubmed:author | pubmed-author:MalekSS | lld:pubmed |
| pubmed-article:9862743 | pubmed:author | pubmed-author:TigheHH | lld:pubmed |
| pubmed-article:9862743 | pubmed:author | pubmed-author:NguyenM DMD | lld:pubmed |
| pubmed-article:9862743 | pubmed:author | pubmed-author:Martin-Orozco... | lld:pubmed |
| pubmed-article:9862743 | pubmed:author | pubmed-author:GiffordTT | lld:pubmed |
| pubmed-article:9862743 | pubmed:author | pubmed-author:Van UdenJJ | lld:pubmed |
| pubmed-article:9862743 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9862743 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9862743 | pubmed:volume | 161 | lld:pubmed |
| pubmed-article:9862743 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9862743 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9862743 | pubmed:pagination | 7054-62 | lld:pubmed |
| pubmed-article:9862743 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9862743 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9862743 | pubmed:articleTitle | Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. | lld:pubmed |
| pubmed-article:9862743 | pubmed:affiliation | Department of Medicine, University of California at San Diego, La Jolla 92093-0635, USA. | lld:pubmed |
| pubmed-article:9862743 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9862743 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9862743 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9862743 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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