| pubmed-article:9862463 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9862463 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9862463 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:9862463 | lifeskim:mentions | umls-concept:C0057459 | lld:lifeskim |
| pubmed-article:9862463 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:9862463 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:9862463 | pubmed:dateCreated | 1999-1-11 | lld:pubmed |
| pubmed-article:9862463 | pubmed:abstractText | We purified DNase II from human liver to apparent homogeneity. The N-terminal amino acid sequences of each of three components constituting the purified mature enzyme were then separately determined by automatic Edman degradation. A combination of this chemical information and the previously reported nucleotide sequence of the cDNA encoding human DNase II [Yasuda et al. (1998) J. Biol. Chem. 273, 2610-2626] allowed detailed elucidation of the enzyme's subunit structure: human DNase II was composed of three non-identical subunits, a propeptide, proprotein and mature protein, following a signal peptide. Expression analysis of a series of deletion mutants derived from the cDNA of DNase II in COS-7 cells suggested that although a single large precursor protein may not be necessary for proteolytic maturation, the propeptide region L17-Q46 may play an essential role in generating the active form of the enzyme. | lld:pubmed |
| pubmed-article:9862463 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9862463 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9862463 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9862463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9862463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9862463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9862463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9862463 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9862463 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9862463 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:9862463 | pubmed:author | pubmed-author:NakashimaYY | lld:pubmed |
| pubmed-article:9862463 | pubmed:author | pubmed-author:YasudaTT | lld:pubmed |
| pubmed-article:9862463 | pubmed:author | pubmed-author:NakajimaTT | lld:pubmed |
| pubmed-article:9862463 | pubmed:author | pubmed-author:MoriSS | lld:pubmed |
| pubmed-article:9862463 | pubmed:author | pubmed-author:KishiKK | lld:pubmed |
| pubmed-article:9862463 | pubmed:author | pubmed-author:TakeshitaHH | lld:pubmed |
| pubmed-article:9862463 | pubmed:author | pubmed-author:NomotoHH | lld:pubmed |
| pubmed-article:9862463 | pubmed:author | pubmed-author:MANNS HSH | lld:pubmed |
| pubmed-article:9862463 | pubmed:author | pubmed-author:HosomiOO | lld:pubmed |
| pubmed-article:9862463 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9862463 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:9862463 | pubmed:volume | 440 | lld:pubmed |
| pubmed-article:9862463 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9862463 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9862463 | pubmed:pagination | 239-42 | lld:pubmed |
| pubmed-article:9862463 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9862463 | pubmed:meshHeading | pubmed-meshheading:9862463-... | lld:pubmed |
| pubmed-article:9862463 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9862463 | pubmed:articleTitle | Identification of the three non-identical subunits constituting human deoxyribonuclease II. | lld:pubmed |
| pubmed-article:9862463 | pubmed:affiliation | Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Japan. | lld:pubmed |
| pubmed-article:9862463 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9862463 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9862463 | lld:pubmed |
