| pubmed-article:9857200 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9857200 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:9857200 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:9857200 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:9857200 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:9857200 | lifeskim:mentions | umls-concept:C0123538 | lld:lifeskim |
| pubmed-article:9857200 | lifeskim:mentions | umls-concept:C0036576 | lld:lifeskim |
| pubmed-article:9857200 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:9857200 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:9857200 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:9857200 | lifeskim:mentions | umls-concept:C0444930 | lld:lifeskim |
| pubmed-article:9857200 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:9857200 | pubmed:dateCreated | 1999-2-16 | lld:pubmed |
| pubmed-article:9857200 | pubmed:abstractText | Endonucleolytic cleavage of pre-mRNAs is the first step during eukaryotic mRNA 3' end formation. It has been proposed that cleavage factors CF IA, CF IB and CF II are required for pre-mRNA 3' end cleavage in yeast. CF IB is composed of a single polypeptide, Nab4p/Hrp1p, which is related to the A/B group of metazoan heterogeneous nuclear ribonucleoproteins (hnRNPs) that function as antagonistic regulators of 5' splice site selection. Here, we provide evidence that Nab4p/Hrp1p is not required for pre-mRNA 3' end endonucleolytic cleavage. We show that CF IA and CF II devoid of Nab4p/Hrp1p are sufficient to cleave a variety of RNA substrates but that cleavage occurs at multiple sites. Addition of Nab4p/Hrp1p prevents these alternative cleavages in a concentration-dependent manner, suggesting an essential and conserved role for some hnRNPs in pre-mRNA cleavage site selection. | lld:pubmed |
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| pubmed-article:9857200 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9857200 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9857200 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9857200 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9857200 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9857200 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9857200 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:9857200 | pubmed:author | pubmed-author:KellerWW | lld:pubmed |
| pubmed-article:9857200 | pubmed:author | pubmed-author:BeyerKK | lld:pubmed |
| pubmed-article:9857200 | pubmed:author | pubmed-author:HectorR ERE | lld:pubmed |
| pubmed-article:9857200 | pubmed:author | pubmed-author:SwansonM SMS | lld:pubmed |
| pubmed-article:9857200 | pubmed:author | pubmed-author:Minvielle-Seb... | lld:pubmed |
| pubmed-article:9857200 | pubmed:author | pubmed-author:KrecicA MAM | lld:pubmed |
