| pubmed-article:9852285 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9852285 | lifeskim:mentions | umls-concept:C0021344 | lld:lifeskim |
| pubmed-article:9852285 | lifeskim:mentions | umls-concept:C1335749 | lld:lifeskim |
| pubmed-article:9852285 | lifeskim:mentions | umls-concept:C1709900 | lld:lifeskim |
| pubmed-article:9852285 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:9852285 | lifeskim:mentions | umls-concept:C0080055 | lld:lifeskim |
| pubmed-article:9852285 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:9852285 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:9852285 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9852285 | pubmed:dateCreated | 1999-3-1 | lld:pubmed |
| pubmed-article:9852285 | pubmed:abstractText | The presence and distribution of high-risk human papillomavirus (HPV) DNA type-16 and -18 or overexpression of the p53 protein were determined in 31 patients with renal pelvic and ureteral carcinoma in Saga prefecture of Japan, consisting of 28 transitional cell carcinomas (TCCs) and 3 squamous cell carcinomas (SCCs). In situ hybridization with DNA probes for HPV-16 and -18 was performed as well as immunohistochemical techniques using antibody to p53 protein. Fresh tumor tissues from 8 patients were also studied for p53 mutations in exons 5 through 8 by direct sequencing. Of 28 TCC patients at Saga prefecture in Japan, 10 tested were positive for HPV DNA, 5 for HPV type-16, 4 for HPV type-18 and one doubly-positive case. Of the remaining 18 tumors, seven showed positive nuclear staining in cancer cells with p53 antibody. One of the 3 patients with SCCs also revealed the nuclear positivity of the cancer cells with p53 antibody but not with HPV infection. p53 point mutation was detected in 2 cases also showing p53 immunopositivity. Overexpressed p53 protein was statistically more common in invasive and non-papillary (p<0.05) and in high-grade TCCs (p<0.05). These findings suggest that HPV infection, and expression (mutation) of p53 protein may be intimately related to the pathogenesis of urothelial tumor cell growth and progression. | lld:pubmed |
| pubmed-article:9852285 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9852285 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9852285 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9852285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9852285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9852285 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9852285 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9852285 | pubmed:issn | 1107-3756 | lld:pubmed |
| pubmed-article:9852285 | pubmed:author | pubmed-author:OhtsukiYY | lld:pubmed |
| pubmed-article:9852285 | pubmed:author | pubmed-author:KagawaSS | lld:pubmed |
| pubmed-article:9852285 | pubmed:author | pubmed-author:KuwaharaMM | lld:pubmed |
| pubmed-article:9852285 | pubmed:author | pubmed-author:FurihataMM | lld:pubmed |
| pubmed-article:9852285 | pubmed:author | pubmed-author:FujisakiNN | lld:pubmed |
| pubmed-article:9852285 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9852285 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:9852285 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9852285 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9852285 | pubmed:pagination | 703-7 | lld:pubmed |
| pubmed-article:9852285 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9852285 | pubmed:meshHeading | pubmed-meshheading:9852285-... | lld:pubmed |
| pubmed-article:9852285 | pubmed:meshHeading | pubmed-meshheading:9852285-... | lld:pubmed |
| pubmed-article:9852285 | pubmed:meshHeading | pubmed-meshheading:9852285-... | lld:pubmed |
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| pubmed-article:9852285 | pubmed:meshHeading | pubmed-meshheading:9852285-... | lld:pubmed |
| pubmed-article:9852285 | pubmed:meshHeading | pubmed-meshheading:9852285-... | lld:pubmed |
| pubmed-article:9852285 | pubmed:meshHeading | pubmed-meshheading:9852285-... | lld:pubmed |
| pubmed-article:9852285 | pubmed:meshHeading | pubmed-meshheading:9852285-... | lld:pubmed |
| pubmed-article:9852285 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9852285 | pubmed:articleTitle | Determination of p53 protein and high-risk human papillomavirus DNA in carcinomas of the renal pelvis and ureter. | lld:pubmed |
| pubmed-article:9852285 | pubmed:affiliation | Department of Urology, Fujisaki Hospital, Karatsu, Saga 847, Japan. | lld:pubmed |
| pubmed-article:9852285 | pubmed:publicationType | Journal Article | lld:pubmed |
