| pubmed-article:9851582 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9851582 | lifeskim:mentions | umls-concept:C0013030 | lld:lifeskim |
| pubmed-article:9851582 | lifeskim:mentions | umls-concept:C0063146 | lld:lifeskim |
| pubmed-article:9851582 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9851582 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:9851582 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:9851582 | lifeskim:mentions | umls-concept:C0056913 | lld:lifeskim |
| pubmed-article:9851582 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:9851582 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:9851582 | pubmed:dateCreated | 1999-2-9 | lld:pubmed |
| pubmed-article:9851582 | pubmed:abstractText | The potential new iron-chelator cytisine and the radical scavenger N-tert-butyl-alpha-(2-sulfophenyl) nitrone (S-PBN) were incubated in a Fenton system and hydroxyl radical formation was measured with the salicylate trapping assay. Both cytisine and S-PBN reduced hydroxyl radical formation in a concentration-dependent manner. For in vivo studies, C57BL/6 mice were injected repeatedly with cytisine (0.5 mg/kg or 2.0 mg/kg s.c.) or saline seven days before and after a single 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection (30 mg/kg s.c.). Seven days after MPTP treatment alone dopamine levels were significantly reduced to 12% of the control values (p < 0.001), whereas MPTP + cytisine treatment (2 mg/kg) led to more than twofold higher dopamine levels (p < 0.01) compared with MPTP alone. We have shown for the first time that cytisine attenuates hydroxyl radical formation in vitro and reduces MPTP-induced dopamine depletion. Thus, cytisine may be useful for the treatment of Parkinson's Disease where the chelation of iron ions could prevent neuronal cell death. | lld:pubmed |
| pubmed-article:9851582 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9851582 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9851582 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9851582 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9851582 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9851582 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9851582 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9851582 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9851582 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9851582 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9851582 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9851582 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9851582 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9851582 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9851582 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9851582 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:9851582 | pubmed:author | pubmed-author:KuschinskyKK | lld:pubmed |
| pubmed-article:9851582 | pubmed:author | pubmed-author:SeiteRR | lld:pubmed |
| pubmed-article:9851582 | pubmed:author | pubmed-author:SprattCC | lld:pubmed |
| pubmed-article:9851582 | pubmed:author | pubmed-author:FergerBB | lld:pubmed |
| pubmed-article:9851582 | pubmed:author | pubmed-author:TeismannPP | lld:pubmed |
| pubmed-article:9851582 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9851582 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:9851582 | pubmed:volume | 360 | lld:pubmed |
| pubmed-article:9851582 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9851582 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9851582 | pubmed:pagination | 155-63 | lld:pubmed |
| pubmed-article:9851582 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9851582 | pubmed:meshHeading | pubmed-meshheading:9851582-... | lld:pubmed |
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| pubmed-article:9851582 | pubmed:meshHeading | pubmed-meshheading:9851582-... | lld:pubmed |
| pubmed-article:9851582 | pubmed:meshHeading | pubmed-meshheading:9851582-... | lld:pubmed |
| pubmed-article:9851582 | pubmed:meshHeading | pubmed-meshheading:9851582-... | lld:pubmed |
| pubmed-article:9851582 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9851582 | pubmed:articleTitle | Effects of cytisine on hydroxyl radicals in vitro and MPTP-induced dopamine depletion in vivo. | lld:pubmed |
| pubmed-article:9851582 | pubmed:affiliation | Institute of Pharmacology and Toxicology, Faculty of Pharmacy, University of Marburg, Germany. ferger@mailer.uni-marburg.de | lld:pubmed |
| pubmed-article:9851582 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9851582 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9851582 | lld:pubmed |
