| pubmed-article:9849881 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9849881 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:9849881 | lifeskim:mentions | umls-concept:C0387583 | lld:lifeskim |
| pubmed-article:9849881 | lifeskim:mentions | umls-concept:C1120843 | lld:lifeskim |
| pubmed-article:9849881 | lifeskim:mentions | umls-concept:C1366876 | lld:lifeskim |
| pubmed-article:9849881 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:9849881 | lifeskim:mentions | umls-concept:C1171350 | lld:lifeskim |
| pubmed-article:9849881 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9849881 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:9849881 | pubmed:dateCreated | 1998-12-23 | lld:pubmed |
| pubmed-article:9849881 | pubmed:abstractText | The mechanism by which p38 mitogen-activated protein kinase (MAPK) regulates the induction of cyclooxygenase (COX)-2 by interleukin-1 (IL-1) has been investigated in HeLa cells. SB 203580, an inhibitor of p38 MAPK, in the range 0.1-1 microM inhibited IL-1-stimulated PGE2 (but not arachidonic acid) release and this was associated with inhibition of induction of COX-2 protein and mRNA. IL-1 stimulated COX-2 transcription in HeLa cells about 2-fold as judged by both reporter gene and nuclear run-on assays. The inhibitor had no significant effect on this. However, in cells previously stimulated with IL-1 it caused rapid destabilisation of COX-2 mRNA independently of on-going transcription. The results suggest a novel function for p38 MAPK in the regulation of mRNA stability. | lld:pubmed |
| pubmed-article:9849881 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9849881 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9849881 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9849881 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9849881 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9849881 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:9849881 | pubmed:author | pubmed-author:SaklatvalaJJ | lld:pubmed |
| pubmed-article:9849881 | pubmed:author | pubmed-author:ClarkA RAR | lld:pubmed |
| pubmed-article:9849881 | pubmed:author | pubmed-author:BrookMM | lld:pubmed |
| pubmed-article:9849881 | pubmed:author | pubmed-author:SarsfieldS... | lld:pubmed |
| pubmed-article:9849881 | pubmed:author | pubmed-author:DeanJ LJL | lld:pubmed |
| pubmed-article:9849881 | pubmed:author | pubmed-author:RidleyS HSH | lld:pubmed |
| pubmed-article:9849881 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9849881 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:9849881 | pubmed:volume | 439 | lld:pubmed |
| pubmed-article:9849881 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9849881 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9849881 | pubmed:pagination | 75-80 | lld:pubmed |
| pubmed-article:9849881 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9849881 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9849881 | pubmed:articleTitle | A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA. | lld:pubmed |
| pubmed-article:9849881 | pubmed:affiliation | Kennedy Institute of Rheumatology, London, UK. | lld:pubmed |
| pubmed-article:9849881 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9849881 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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