| pubmed-article:9848784 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9848784 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:9848784 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
| pubmed-article:9848784 | lifeskim:mentions | umls-concept:C0011881 | lld:lifeskim |
| pubmed-article:9848784 | lifeskim:mentions | umls-concept:C0596611 | lld:lifeskim |
| pubmed-article:9848784 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9848784 | pubmed:dateCreated | 1999-4-19 | lld:pubmed |
| pubmed-article:9848784 | pubmed:abstractText | PCR assays were established for easy and fast analysis of two transforming growth factor-beta1 (TGF-beta1) gene mutations, a C to T transition at position 76 in exon 5 resulting in a change from threonine to isoleucine in position 263 (Thr263Ile) of the propeptide and a deletion of a C in the intron sequence eight bases prior to exon 5 (713-8delC). These mutations were evaluated in insulin-dependent diabetes mellitus (IDDM) patients (n = 137) and control subjects (n = 105) and in IDDM patients with (n = 170) and without (n = 99) nephropathy. After evaluating intra- and interindividual variation in TGF-beta1 expression levels, the TGF-beta1 mRNA level in phorbol 12-myristate-13-acetate-stimulated (1 ng/ml) lymphocytes from individuals with different TGF-beta1 genotypes was also studied. No association of the two TGF-beta1 sequence variations with IDDM in general was found. However, a weak but significant association of the Thr263Ile mutation with diabetic nephropathy was found (P = 0.03). No correlation between TGF-beta1 transcription level and genotype of any of the two studied polymorphisms was found. However, significant interindividual differences in TGF-beta1 mRNA levels were observed between the tested individuals (P < 0.0001) compatible with a genetic control mechanism of TGF-beta1 synthesis at the mRNA level. | lld:pubmed |
| pubmed-article:9848784 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9848784 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9848784 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9848784 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9848784 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9848784 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9848784 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9848784 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9848784 | pubmed:issn | 1046-6673 | lld:pubmed |
| pubmed-article:9848784 | pubmed:author | pubmed-author:NerupJJ | lld:pubmed |
| pubmed-article:9848784 | pubmed:author | pubmed-author:JohannesenJJ | lld:pubmed |
| pubmed-article:9848784 | pubmed:author | pubmed-author:HansenP MPM | lld:pubmed |
| pubmed-article:9848784 | pubmed:author | pubmed-author:PociotFF | lld:pubmed |
| pubmed-article:9848784 | pubmed:author | pubmed-author:KarlsenA EAE | lld:pubmed |
| pubmed-article:9848784 | pubmed:author | pubmed-author:LangdahlB LBL | lld:pubmed |
| pubmed-article:9848784 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9848784 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:9848784 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9848784 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9848784 | pubmed:pagination | 2302-7 | lld:pubmed |
| pubmed-article:9848784 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9848784 | pubmed:meshHeading | pubmed-meshheading:9848784-... | lld:pubmed |
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| pubmed-article:9848784 | pubmed:meshHeading | pubmed-meshheading:9848784-... | lld:pubmed |
| pubmed-article:9848784 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9848784 | pubmed:articleTitle | TGF-beta1 gene mutations in insulin-dependent diabetes mellitus and diabetic nephropathy. | lld:pubmed |
| pubmed-article:9848784 | pubmed:affiliation | Steno Diabetes Center, Gentofte, Denmark. | lld:pubmed |
| pubmed-article:9848784 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9848784 | pubmed:publicationType | Comparative Study | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9848784 | lld:pubmed |
