| pubmed-article:9844102 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9844102 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9844102 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:9844102 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9844102 | lifeskim:mentions | umls-concept:C0030520 | lld:lifeskim |
| pubmed-article:9844102 | lifeskim:mentions | umls-concept:C0205950 | lld:lifeskim |
| pubmed-article:9844102 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9844102 | lifeskim:mentions | umls-concept:C1852403 | lld:lifeskim |
| pubmed-article:9844102 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9844102 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9844102 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9844102 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9844102 | pubmed:dateCreated | 1999-2-3 | lld:pubmed |
| pubmed-article:9844102 | pubmed:abstractText | Parathyroid hormone (PTH) regulates gene expression in skeletal osteoblasts mainly through the cAMP-protein kinase A (PKA) pathway. In neuroendocrine cells, activation of the cAMP-PKA signaling pathway leads to induction of the inducible cAMP early repressor (ICER), which is transcribed from an intronic promoter of the CREM gene and acts as a transcriptional repressor. To investigate whether PTH induces ICER expression in osteoblastic cells, RNA from MC3T3-E1 cells was subjected to reverse transcriptase-polymerase chain reaction using primers spanning the ICER sequence. Amplified products were subcloned, sequenced, and used as a probe for Northern blot analysis. In MC3T3-E1 cells, PTH induced ICER mRNA levels, which peaked at 2 h and declined to baseline by 8 h. Cycloheximide caused superinduction of ICER mRNA in response to PTH. In cultured mouse calvariae, PTH also induced ICER mRNA accumulation, which peaked at 2 h and returned almost to baseline by 10 h. Overexpression of ICER IIgamma decreased both baseline and PTH-stimulated prostaglandin G/H synthase 2 promoter activity in MC3T3-E1 cells. The induction of ICER represents a novel mechanism by which PTH regulates gene expression in osteoblastic cells. | lld:pubmed |
| pubmed-article:9844102 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9844102 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9844102 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9844102 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9844102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9844102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9844102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9844102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9844102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9844102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9844102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9844102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9844102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9844102 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9844102 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9844102 | pubmed:issn | 0884-0431 | lld:pubmed |
| pubmed-article:9844102 | pubmed:author | pubmed-author:KreamB EBE | lld:pubmed |
| pubmed-article:9844102 | pubmed:author | pubmed-author:NemotoKK | lld:pubmed |
| pubmed-article:9844102 | pubmed:author | pubmed-author:TetradisSS | lld:pubmed |
| pubmed-article:9844102 | pubmed:author | pubmed-author:NervinaJ MJM | lld:pubmed |
| pubmed-article:9844102 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9844102 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:9844102 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9844102 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9844102 | pubmed:pagination | 1846-51 | lld:pubmed |
| pubmed-article:9844102 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:9844102 | pubmed:meshHeading | pubmed-meshheading:9844102-... | lld:pubmed |
| pubmed-article:9844102 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9844102 | pubmed:articleTitle | Parathyroid hormone induces expression of the inducible cAMP early repressor in osteoblastic MC3T3-E1 cells and mouse calvariae. | lld:pubmed |
| pubmed-article:9844102 | pubmed:affiliation | Department of Oral Diagnosis, School of Dental Medicine, The University of Connecticut Health Center, Farmington, Connecticut, USA. | lld:pubmed |
| pubmed-article:9844102 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9844102 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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