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pubmed-article:9843537pubmed:abstractTextWe measured significant undershoots of the concentrations of free ADP ([ADP]) and Pi ([Pi]) and the free energy of ATP hydrolysis (DeltaGATP) below initial resting levels during recovery from severe ischemic exercise with 31P-nuclear magnetic resonance spectroscopy in 11 healthy sports students. Undershoots of the rate of oxidative phosphorylation would be predicted if the rate of oxidative phosphorylation would depend solely on free [ADP], [Pi], or DeltaGATP. However, undershoots of the rate of oxidative phosphorylation have not been reported in the literature. Furthermore, undershoots of the rate of oxidative phosphorylation are unlikely because there is evidence that a balance between ATP production and consumption cannot be achieved if an undershoot of the rate of oxidative phosphorylation actually occurs. Therefore, oxidative phosphorylation seems to depend not only on free [ADP], [Pi], or DeltaGATP. An explanation is that acidosis-related or other factors control oxidative phosphorylation additionally, at least under some conditions.lld:pubmed
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pubmed-article:9843537pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:9843537pubmed:articleTitleRecovery of free ADP, Pi, and free energy of ATP hydrolysis in human skeletal muscle.lld:pubmed
pubmed-article:9843537pubmed:affiliationDepartment of Physiology, German Sports University, D-50933 Cologne, Germany. h.wackerhage@uclan.ac.uklld:pubmed
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