| pubmed-article:9843499 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9843499 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:9843499 | lifeskim:mentions | umls-concept:C0001271 | lld:lifeskim |
| pubmed-article:9843499 | lifeskim:mentions | umls-concept:C0678544 | lld:lifeskim |
| pubmed-article:9843499 | lifeskim:mentions | umls-concept:C1421479 | lld:lifeskim |
| pubmed-article:9843499 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9843499 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:9843499 | lifeskim:mentions | umls-concept:C0680829 | lld:lifeskim |
| pubmed-article:9843499 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:9843499 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:9843499 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:9843499 | pubmed:dateCreated | 1999-2-11 | lld:pubmed |
| pubmed-article:9843499 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9843499 | pubmed:abstractText | Rac is a Rho-family small GTPase that induces the formation of membrane ruffles. However, it is poorly understood how Rac-induced reorganization of the actin cytoskeleton, which is essential for ruffle formation, is regulated. Here we identify a novel Wiskott-Aldrich syndrome protein (WASP)-family protein, WASP family Verprolin-homologous protein (WAVE), as a regulator of actin reorganization downstream of Rac. Ectopically expressed WAVE induces the formation of actin filament clusters that overlap with the expressed WAVE itself. In this actin clustering, profilin, a monomeric actin-binding protein that has been suggested to be involved in actin polymerization, was shown to be essential. The expression of a dominant-active Rac mutant induces the translocation of endogenous WAVE from the cytosol to membrane ruffling areas. Furthermore, the co-expression of a deltaVPH WAVE mutant that cannot induce actin reorganization specifically suppresses the ruffle formation induced by Rac, but has no effect on Cdc42-induced actin-microspike formation, a phenomenon that is also known to be dependent on rapid actin reorganization. The deltaVPH WAVE also suppresses membrane-ruffling formation induced by platelet-derived growth factor in Swiss 3T3 cells. Taken together, we conclude that WAVE plays a critical role downstream of Rac in regulating the actin cytoskeleton required for membrane ruffling. | lld:pubmed |
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| pubmed-article:9843499 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9843499 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9843499 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9843499 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9843499 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9843499 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9843499 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:9843499 | pubmed:author | pubmed-author:TakenawaTT | lld:pubmed |
| pubmed-article:9843499 | pubmed:author | pubmed-author:MikiHH | lld:pubmed |
| pubmed-article:9843499 | pubmed:author | pubmed-author:SuetsuguSS | lld:pubmed |
| pubmed-article:9843499 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9843499 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9843499 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:9843499 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9843499 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9843499 | pubmed:pagination | 6932-41 | lld:pubmed |
| pubmed-article:9843499 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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