| pubmed-article:9841488 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9841488 | lifeskim:mentions | umls-concept:C0175677 | lld:lifeskim |
| pubmed-article:9841488 | lifeskim:mentions | umls-concept:C0600534 | lld:lifeskim |
| pubmed-article:9841488 | lifeskim:mentions | umls-concept:C0022663 | lld:lifeskim |
| pubmed-article:9841488 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:9841488 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:9841488 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9841488 | lifeskim:mentions | umls-concept:C1412113 | lld:lifeskim |
| pubmed-article:9841488 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9841488 | lifeskim:mentions | umls-concept:C1958507 | lld:lifeskim |
| pubmed-article:9841488 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:9841488 | pubmed:issue | 6 Pt 2 | lld:pubmed |
| pubmed-article:9841488 | pubmed:dateCreated | 1998-11-5 | lld:pubmed |
| pubmed-article:9841488 | pubmed:abstractText | To elucidate the contribution of the renin-angiontensin system (RAS) to glomerular injury in salt-sensitive hypertension, we investigated the chronic effects of the angiotensin I-converting enzyme inhibitor cilazapril and the angiotensin II type 1-receptor antagonist (AT1a) TCV-116 in Dahl-Iwai rats. Dahl salt-sensitive (S) rats receiving 8% salt diet for 6 wk were simultaneously treated with cilazapril (n = 6), TCV-116 (n = 6), or saline (n = 14). The 8% salt diet markedly increased systolic blood pressure (SBP), urinary protein, and N-acetyl-beta-glucosaminidase (NAG) excretion compared with 0.3% salt-treated S (n = 6) or salt-resistant (n = 6) rats. Although neither cilazapril nor TCV-116 reduced the elevated SBP, TCV-116 significantly lowered urinary protein and NAG excretion. Histologically, 8% salt treatment in S rats induced progressive sclerotic and proliferative glomerular changes, which were ameliorated by both drugs. TCV-116 increased the glomerular diameter. Immunofluorescence demonstrated the increased level of type III collagen in the mesangium of 8% salt-treated S rats, which was completely reversed by TCV-116. Competitive RT-PCR of mRNA extracted from the glomeruli revealed that 8% salt treatment significantly increased the levels of proliferating cell nuclear antigen (PCNA) and platelet-derived growth factor B-chain and that TCV-116 significantly reduced the levels of PCNA and transforming growth factor-beta1 (TGF-beta1). Thus, although the chronic RAS-inhibition in salt-sensitive hypertension exerted a histologically renoprotective effect by both ways without lowering blood pressure, the RAS inhibition due to AT1a had more beneficial advantages of reducing proteinuria and attenuating the levels of glomerular TGF-beta1 and extracellular matrix. | lld:pubmed |
| pubmed-article:9841488 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9841488 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9841488 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9841488 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9841488 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9841488 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9841488 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9841488 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:9841488 | pubmed:author | pubmed-author:YamauchiTT | lld:pubmed |
| pubmed-article:9841488 | pubmed:author | pubmed-author:MakinoHH | lld:pubmed |
| pubmed-article:9841488 | pubmed:author | pubmed-author:MimuraYY | lld:pubmed |
| pubmed-article:9841488 | pubmed:author | pubmed-author:OguraTT | lld:pubmed |
| pubmed-article:9841488 | pubmed:author | pubmed-author:OtsukaFF | lld:pubmed |
| pubmed-article:9841488 | pubmed:author | pubmed-author:KataokaHH | lld:pubmed |
| pubmed-article:9841488 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9841488 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:9841488 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9841488 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9841488 | pubmed:pagination | R1797-806 | lld:pubmed |
| pubmed-article:9841488 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:9841488 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9841488 | pubmed:articleTitle | Effects of chronic inhibition of ACE and AT1 receptors on glomerular injury in dahl salt-sensitive rats. | lld:pubmed |
| pubmed-article:9841488 | pubmed:affiliation | Department of Medicine III, Okayama University Medical School, Okayama University, Okayama 700-8558 Japan. | lld:pubmed |
| pubmed-article:9841488 | pubmed:publicationType | Journal Article | lld:pubmed |
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