| pubmed-article:9837859 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9837859 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9837859 | lifeskim:mentions | umls-concept:C0024880 | lld:lifeskim |
| pubmed-article:9837859 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:9837859 | lifeskim:mentions | umls-concept:C0019605 | lld:lifeskim |
| pubmed-article:9837859 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:9837859 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:9837859 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9837859 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:9837859 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:9837859 | lifeskim:mentions | umls-concept:C0021492 | lld:lifeskim |
| pubmed-article:9837859 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:9837859 | pubmed:dateCreated | 1999-1-7 | lld:pubmed |
| pubmed-article:9837859 | pubmed:abstractText | RANTES (regulated upon activation, normal T cell expressed and presumably secreted) and other chemoattractant proteins are members of the intercrine or chemokine family of proinflammatory basic polypeptides. RANTES is a prototype of the C-C chemokine subfamily that acts as a selective chemoattractant for human monocytes and CD4-positive lymphocytes and increases the adherence of monocytes to endothelial cells. However, the role of RANTES in white cells is still unclear. We report here that hrRANTES at 20 ng/50 microl in mice causes mast cell recruitment 4 h after intramuscular injection, an effect inhibited by anti-RANTES, as evidenced by 0.1% Toluidine blue, a specific dye for coloring mast cells. Injections of PBS (50 microl) vehicle (negative control) did not produce any appreciable inflammatory response, whereas injection of lipopolysaccharide 20 ng/50 microl (positive control) generated a marked inflammatory state. When RANTES was injected intramuscularly in genetically mast cell-deficient W/Wv mice, the inflammatory effect was not present. The RANTES injection sites were then excised and studied under an optical and electron microscope. A Northern blot analysis was performed using a probe that was prepared to detect mRNA encoding the histidine decarboxylase (HDC) gene on excised muscle tissue. We found that hrRANTES provoked generation of HDC mRNA from muscle tissue after 4 h. These effects were inhibited by an anti-RANTES antibody and were absent in genetically mast cell-deficient mice. The increasing number of mast cells in the RANTES injection sites led to an augmentation of histamine content compared to controls (PBS). The injection of hrRANTES 20 ng/20 microl into the sole of a rat paw confirmed the inflammatory and the mast cell recruitment potential of this chemokine. In these studies, hrRANTES injections in muscle tissue provided direct in vivo evidence that RANTES has a significant effect on mast cell recruitment and HDC mRNA generation. | lld:pubmed |
| pubmed-article:9837859 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9837859 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9837859 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9837859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9837859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9837859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9837859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9837859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9837859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9837859 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9837859 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9837859 | pubmed:issn | 0892-6638 | lld:pubmed |
| pubmed-article:9837859 | pubmed:author | pubmed-author:RealeMM | lld:pubmed |
| pubmed-article:9837859 | pubmed:author | pubmed-author:TheoharidesT... | lld:pubmed |
| pubmed-article:9837859 | pubmed:author | pubmed-author:ContiPP | lld:pubmed |
| pubmed-article:9837859 | pubmed:author | pubmed-author:LetourneauRR | lld:pubmed |
| pubmed-article:9837859 | pubmed:author | pubmed-author:BarbacaneR... | lld:pubmed |
| pubmed-article:9837859 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9837859 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:9837859 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9837859 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9837859 | pubmed:pagination | 1693-700 | lld:pubmed |
| pubmed-article:9837859 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9837859 | pubmed:meshHeading | pubmed-meshheading:9837859-... | lld:pubmed |
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| pubmed-article:9837859 | pubmed:meshHeading | pubmed-meshheading:9837859-... | lld:pubmed |
| pubmed-article:9837859 | pubmed:meshHeading | pubmed-meshheading:9837859-... | lld:pubmed |
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| pubmed-article:9837859 | pubmed:meshHeading | pubmed-meshheading:9837859-... | lld:pubmed |
| pubmed-article:9837859 | pubmed:meshHeading | pubmed-meshheading:9837859-... | lld:pubmed |
| pubmed-article:9837859 | pubmed:meshHeading | pubmed-meshheading:9837859-... | lld:pubmed |
| pubmed-article:9837859 | pubmed:meshHeading | pubmed-meshheading:9837859-... | lld:pubmed |
| pubmed-article:9837859 | pubmed:meshHeading | pubmed-meshheading:9837859-... | lld:pubmed |
| pubmed-article:9837859 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9837859 | pubmed:articleTitle | Intramuscular injection of hrRANTES causes mast cell recruitment and increased transcription of histidine decarboxylase in mice: lack of effects in genetically mast cell-deficient W/WV mice. | lld:pubmed |
| pubmed-article:9837859 | pubmed:affiliation | Immunology Division, University of Chieti School of Medicine, Chieti, Italy. pconti@unich.it | lld:pubmed |
| pubmed-article:9837859 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9837859 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9837859 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9837859 | lld:pubmed |
