| pubmed-article:9837694 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9837694 | lifeskim:mentions | umls-concept:C0121772 | lld:lifeskim |
| pubmed-article:9837694 | lifeskim:mentions | umls-concept:C0032594 | lld:lifeskim |
| pubmed-article:9837694 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:9837694 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9837694 | pubmed:dateCreated | 1999-1-21 | lld:pubmed |
| pubmed-article:9837694 | pubmed:abstractText | Secondary immune responses to T-independent antigens are characterized by little or no affinity maturation, a phenomenon attributed to limited somatic hypermutation. In the human immune response to Haemophilus influenzae type b capsular polysaccharide, however, there are numerous differences between rearranged heavy chain variable region gene segments and candidate germline genes, irrespective of antigen presentation in a T-independent or T-dependent form. To determine the characteristics of somatic hypermutation in this response, we analyzed rearranged heavy chain variable region segments and associated 3' untranslated JH4-JH5 introns from monoclonal anti-Hib PS antibodies. Mutation of untranslated introns and heavy chain variable segments in both T-independent and T-dependent responses resembles that described in murine and unselected human immune responses. Although mutation is frequent in both T-independent and T-dependent anti-Hib PS responses, there is little evidence of antigen-driven selection, suggesting that ongoing pressure to conserve the variable segment germline configuration limits affinity maturation in this immune response. | lld:pubmed |
| pubmed-article:9837694 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9837694 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9837694 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9837694 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9837694 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9837694 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9837694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9837694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9837694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9837694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9837694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9837694 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9837694 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9837694 | pubmed:issn | 0090-1229 | lld:pubmed |
| pubmed-article:9837694 | pubmed:author | pubmed-author:ShackelfordP... | lld:pubmed |
| pubmed-article:9837694 | pubmed:author | pubmed-author:CarrollW LWL | lld:pubmed |
| pubmed-article:9837694 | pubmed:author | pubmed-author:AddersonE EEE | lld:pubmed |
| pubmed-article:9837694 | pubmed:copyrightInfo | Copyright 1998 Academic Press. | lld:pubmed |
| pubmed-article:9837694 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9837694 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:9837694 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9837694 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9837694 | pubmed:pagination | 240-6 | lld:pubmed |
| pubmed-article:9837694 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9837694 | pubmed:meshHeading | pubmed-meshheading:9837694-... | lld:pubmed |
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| pubmed-article:9837694 | pubmed:meshHeading | pubmed-meshheading:9837694-... | lld:pubmed |
| pubmed-article:9837694 | pubmed:meshHeading | pubmed-meshheading:9837694-... | lld:pubmed |
| pubmed-article:9837694 | pubmed:meshHeading | pubmed-meshheading:9837694-... | lld:pubmed |
| pubmed-article:9837694 | pubmed:meshHeading | pubmed-meshheading:9837694-... | lld:pubmed |
| pubmed-article:9837694 | pubmed:meshHeading | pubmed-meshheading:9837694-... | lld:pubmed |
| pubmed-article:9837694 | pubmed:meshHeading | pubmed-meshheading:9837694-... | lld:pubmed |
| pubmed-article:9837694 | pubmed:meshHeading | pubmed-meshheading:9837694-... | lld:pubmed |
| pubmed-article:9837694 | pubmed:meshHeading | pubmed-meshheading:9837694-... | lld:pubmed |
| pubmed-article:9837694 | pubmed:meshHeading | pubmed-meshheading:9837694-... | lld:pubmed |
| pubmed-article:9837694 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9837694 | pubmed:articleTitle | Somatic hypermutation in T-independent and T-dependent immune responses to Haemophilus influenzae type b polysaccharide. | lld:pubmed |
| pubmed-article:9837694 | pubmed:affiliation | Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, 84132, USA. | lld:pubmed |
| pubmed-article:9837694 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9837694 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9837694 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9837694 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9837694 | lld:pubmed |
