| pubmed-article:9835624 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9835624 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9835624 | lifeskim:mentions | umls-concept:C0010674 | lld:lifeskim |
| pubmed-article:9835624 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9835624 | lifeskim:mentions | umls-concept:C0015385 | lld:lifeskim |
| pubmed-article:9835624 | lifeskim:mentions | umls-concept:C0000854 | lld:lifeskim |
| pubmed-article:9835624 | lifeskim:mentions | umls-concept:C0596019 | lld:lifeskim |
| pubmed-article:9835624 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:9835624 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:9835624 | lifeskim:mentions | umls-concept:C0205385 | lld:lifeskim |
| pubmed-article:9835624 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:9835624 | pubmed:dateCreated | 1999-1-8 | lld:pubmed |
| pubmed-article:9835624 | pubmed:abstractText | The cortical thick ascending limb (CTAL) absorbs Cl- via a Na+-K+-Cl- cotransport at the apical membrane and several Cl- channels at the basolateral membrane, including a 9-pS channel having several properties of the cystic fibrosis transmembrane conductance regulator (CFTR). Having checked that CFTR mRNA is present in the mouse CTAL, we investigated whether this channel is a CFTR molecule by applying the patch-clamp technique to CTALs microdissected from CFTR knockout mice (cftrm1Unc). The 9-pS channel was active in cell-attached patches from tubules of mice homozygous for the disrupted cftr gene [CFTR (-/-)] at the same frequency and with the same activity (NPo) as in normal [CFTR (+/+)] or heterozygous [CFTR (+/-)] mice. The conductive properties of the channel, studied on inside-out patches, were identical in CFTR (-/-), CFTR (+/+), and CFTR (+/-) tubules, as were the sensitivities to internal pH and internal ATP, two typical features of this channel. In addition, the Cl- absorption in isolated, microperfused CTALs and the Na+-K+-Cl- cotransport activity were identical in CFTR (-/-), CFTR (+/+), and CFTR (+/-) mice. These results show that the 9-pS Cl- channel is distinct from CFTR, and that the CFTR protein has no influence on the Cl- absorption in this part of the renal tubule. | lld:pubmed |
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| pubmed-article:9835624 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9835624 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9835624 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9835624 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9835624 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9835624 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:9835624 | pubmed:author | pubmed-author:VandewalleAA | lld:pubmed |
| pubmed-article:9835624 | pubmed:author | pubmed-author:MoreauRR | lld:pubmed |
| pubmed-article:9835624 | pubmed:author | pubmed-author:BaillyCC | lld:pubmed |
| pubmed-article:9835624 | pubmed:author | pubmed-author:TeulonJJ | lld:pubmed |
| pubmed-article:9835624 | pubmed:author | pubmed-author:BensMM | lld:pubmed |
| pubmed-article:9835624 | pubmed:author | pubmed-author:PaulaisMM | lld:pubmed |
| pubmed-article:9835624 | pubmed:author | pubmed-author:GuinamardRR | lld:pubmed |
| pubmed-article:9835624 | pubmed:author | pubmed-author:De Jesus... | lld:pubmed |
| pubmed-article:9835624 | pubmed:author | pubmed-author:MarvãoPP | lld:pubmed |
| pubmed-article:9835624 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9835624 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9835624 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:9835624 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9835624 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9835624 | pubmed:pagination | 1986-93 | lld:pubmed |
| pubmed-article:9835624 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9835624 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9835624 | pubmed:articleTitle | Cl- absorption across the thick ascending limb is not altered in cystic fibrosis mice. A role for a pseudo-CFTR Cl- channel. | lld:pubmed |
| pubmed-article:9835624 | pubmed:affiliation | INSERM CJF 95-07, Institut Fédératif de Recherche 02, Faculté de Médecine Xavier Bichat, Paris, France. | lld:pubmed |
| pubmed-article:9835624 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9835624 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9835624 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12638 | entrezgene:pubmed | pubmed-article:9835624 | lld:entrezgene |
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