| pubmed-article:9834143 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9834143 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9834143 | lifeskim:mentions | umls-concept:C0042149 | lld:lifeskim |
| pubmed-article:9834143 | lifeskim:mentions | umls-concept:C0596981 | lld:lifeskim |
| pubmed-article:9834143 | lifeskim:mentions | umls-concept:C0032821 | lld:lifeskim |
| pubmed-article:9834143 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:9834143 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:9834143 | pubmed:dateCreated | 1999-2-1 | lld:pubmed |
| pubmed-article:9834143 | pubmed:abstractText | In freshly dissociated uterine myocytes, the outward current is carried by K+ through channels highly selective for K+. Typically, nonpregnant myocytes have rather noisy K+ currents; half of them also have a fast-inactivating transient outward current (ITO). In contrast, the current records are not noisy in late pregnant myocytes, and ITO densities are low. The whole-cell IK of nonpregnant myocytes respond strongly to changes in [Ca2+]o or changes in [Ca2+]i caused by photolysis of caged Ca2+ compounds, nitr 5 or DM-nitrophene, but that of late-pregnant myocytes respond weakly or not at all. The Ca2+ insensitivity of the latter is present before any exposure to dissociating enzymes. By holding at -80, -40, or 0 mV and digital subtractions, the whole-cell IK of each type of myocyte can be separated into one noninactivating and two inactivating components with half-inactivation at approximately -61 and -22 mV. The noninactivating components, which consist mainly of iberiotoxin-susceptible large-conductance Ca2+-activated K+ currents, are half-activated at 39 mV in nonpregnant myocytes, but at 63 mV in late-pregnant myocytes. In detached membrane patches from the latter, identified 139 pS, Ca2+-sensitive K+ channels also have a half-open probability at 68 mV, and are less sensitive to Ca2+ than similar channels in taenia coli myocytes. Ca2+-activated K+ currents, susceptible to tetraethylammonium, charybdotoxin, and iberiotoxin contribute 30-35% of the total IK in nonpregnant myocytes, but <20% in late-pregnant myocytes. Dendrotoxin-susceptible, small-conductance delayed rectifier currents are not seen in nonpregnant myocytes, but contribute approximately 20% of total IK in late-pregnant myocytes. Thus, in late-pregnancy, myometrial excitability is increased by changes in K+ currents that include a suppression of the ITO, a redistribution of IK expression from large-conductance Ca2+-activated channels to smaller-conductance delayed rectifier channels, a lowered Ca2+ sensitivity, and a positive shift of the activation of some large-conductance Ca2+-activated channels. | lld:pubmed |
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| pubmed-article:9834143 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9834143 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9834143 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9834143 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9834143 | pubmed:issn | 0022-1295 | lld:pubmed |
| pubmed-article:9834143 | pubmed:author | pubmed-author:YoshinoMM | lld:pubmed |
| pubmed-article:9834143 | pubmed:author | pubmed-author:WangS YSY | lld:pubmed |
| pubmed-article:9834143 | pubmed:author | pubmed-author:KaoC YCY | lld:pubmed |
| pubmed-article:9834143 | pubmed:author | pubmed-author:WakuiMM | lld:pubmed |
| pubmed-article:9834143 | pubmed:author | pubmed-author:GutV AVA | lld:pubmed |
| pubmed-article:9834143 | pubmed:author | pubmed-author:KarP KPK | lld:pubmed |
| pubmed-article:9834143 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9834143 | pubmed:volume | 112 | lld:pubmed |
| pubmed-article:9834143 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9834143 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9834143 | pubmed:pagination | 737-56 | lld:pubmed |
| pubmed-article:9834143 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9834143 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9834143 | pubmed:articleTitle | Potassium currents in freshly dissociated uterine myocytes from nonpregnant and late-pregnant rats. | lld:pubmed |
| pubmed-article:9834143 | pubmed:affiliation | Department of Pharmacology, State University of New York Health Science Center, Brooklyn, New York 11203, USA. | lld:pubmed |
| pubmed-article:9834143 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9834143 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:9834143 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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