biomechanical forces generated by blood flow within the cardiovascular system have been proposed as important modulators of regional endothelial phenotype and function. This process is thought to involve the regulation of vascular gene expression by physiological fluid mechanical stimuli such as fluid shear stresses.
Human prostaglandin transporter gene (hPGT) is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivo.
Vascular Research Division, Department of Pathology, and the Cardiovascular Division Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jtopper@leland.stanford.edu
