| pubmed-article:9829964 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9829964 | lifeskim:mentions | umls-concept:C0285558 | lld:lifeskim |
| pubmed-article:9829964 | lifeskim:mentions | umls-concept:C1705328 | lld:lifeskim |
| pubmed-article:9829964 | lifeskim:mentions | umls-concept:C1705341 | lld:lifeskim |
| pubmed-article:9829964 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:9829964 | lifeskim:mentions | umls-concept:C0056695 | lld:lifeskim |
| pubmed-article:9829964 | lifeskim:mentions | umls-concept:C0812228 | lld:lifeskim |
| pubmed-article:9829964 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:9829964 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:9829964 | pubmed:issue | 49 | lld:pubmed |
| pubmed-article:9829964 | pubmed:dateCreated | 1999-1-8 | lld:pubmed |
| pubmed-article:9829964 | pubmed:abstractText | The nuclear factor CREB stimulates the expression of cellular genes following its protein kinase A-mediated phosphorylation at Ser-133. Ser-133 phosphorylation, in turn, activates target gene expression by promoting recruitment of the co-activator CBP. Recent studies showing that CREB and its paralog CREM are required for survival of certain cell types prompted us to examine whether CREB is a nuclear target for activation via the growth factor-dependent Ser/Thr kinase Akt/PKB. When overexpressed in serum-stimulated cells, Akt/PKB potently induced Ser-133 phosphorylation of CREB and promoted recruitment of CBP. Correspondingly, Akt/PKB stimulated target gene expression via CREB in a phospho(Ser-133)-dependent manner. Akt/PKB induced CREB activity only in response to serum stimulation, and this effect was suppressed by the phosphatidylinositol 3-kinase inhibitor LY 294002. Our results support the notion that Akt/PKB promotes cell survival, at least in part, by stimulating the expression of cellular genes via the CREB/CBP nuclear transduction pathway. | lld:pubmed |
| pubmed-article:9829964 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9829964 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9829964 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9829964 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9829964 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9829964 | pubmed:author | pubmed-author:HayH RHR | lld:pubmed |
| pubmed-article:9829964 | pubmed:author | pubmed-author:MontminyMM | lld:pubmed |
| pubmed-article:9829964 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9829964 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:9829964 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9829964 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9829964 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9829964 | pubmed:pagination | 32377-9 | lld:pubmed |
| pubmed-article:9829964 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9829964 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9829964 | pubmed:articleTitle | CREB is a regulatory target for the protein kinase Akt/PKB. | lld:pubmed |
| pubmed-article:9829964 | pubmed:affiliation | Joslin Diabetes Center, Research Division, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02215, USA. | lld:pubmed |
| pubmed-article:9829964 | pubmed:publicationType | Journal Article | lld:pubmed |
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