Ifosfamide and vinorelbine: an active regimen for patients with relapsed or refractory Hodgkin's disease.

Source:http://linkedlifedata.com/resource/pubmed/id/9827930

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Authors

Bonadonna G, Valagussa P, Santoro A, Bonfanti R, Zanini M, Viviani S, Devizzi L, Di Russo A, Soncini F, Soto Parra H

Affiliation

Division of Medical Oncology A, Istituto Nazionale Tumori, Milan, Italy.

Abstract

Twenty-six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m2/d, days 1-4 through continuous intravenous infusion) and vinorelbine (25 mg/m2, i.v. days 1 and 5) with mesna uroprotection and G-CSF support. Courses were given at 3-week intervals. Ten patients achieved a complete and 10 patients a partial response, yielding an overall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.

PMID
9827930

Publication types

Clinical Trial