| pubmed-article:9827903 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9827903 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9827903 | lifeskim:mentions | umls-concept:C0376152 | lld:lifeskim |
| pubmed-article:9827903 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:9827903 | lifeskim:mentions | umls-concept:C0882849 | lld:lifeskim |
| pubmed-article:9827903 | lifeskim:mentions | umls-concept:C0007586 | lld:lifeskim |
| pubmed-article:9827903 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
| pubmed-article:9827903 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:9827903 | lifeskim:mentions | umls-concept:C1413221 | lld:lifeskim |
| pubmed-article:9827903 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9827903 | pubmed:dateCreated | 1998-12-29 | lld:pubmed |
| pubmed-article:9827903 | pubmed:abstractText | Retinoids, especially all-trans-retinoic acid (ATRA), are well known for their differentiating activity on HL-60 cells. Moreover ATRA induces CD38 antigen overexpression on these cells. In this study we examined the effects of ATRA on purified normal CD34+ cells from adult human marrows incubated with ATRA (1 microM) or stem cell factor (SCF) after 7 d liquid cultures in serum-deprived medium. Before and after the incubation, CD34+ cells were studied by flow cytometry to evaluate the cell-surface expression of CD38 and c-Kit antigens and the cycle status of these cells using high-resolution analysis (DNA content v Ki-67 antigen expression) to clarify the functional meaning of antigenic variations. When compared with control cultures, ATRA-treated cells displayed changes in their immunophenotypic profile. Particularly relevant was the up-regulation of CD38 antigen with a mean (+/-SEM) fold increase of 21 +/- 0.1 (P=0.028) for geometric mean fluorescence intensity (GMFI), without modulation of c-Kit expression. SCF only down-regulated expression of c-Kit with a fold decrease of 4.6 +/- 0.9 for GMFI (P=0.043). Unlike SCF, ATRA did not induce CD34+ cells to entry into cell cycle despite increased levels of surface CD38 antigen. Moreover morphological and functional assays did not argue for an ATRA-induced maturation process. Contrary to steady-state cells, CD34+ cells treated with pharmacological doses of ATRA alone displayed CD38 over-expression without change in c-Kit levels and cycle status, suggesting an absence of maturation pressure. | lld:pubmed |
| pubmed-article:9827903 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9827903 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9827903 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9827903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9827903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9827903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9827903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9827903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9827903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9827903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9827903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9827903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9827903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9827903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9827903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9827903 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9827903 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9827903 | pubmed:issn | 0007-1048 | lld:pubmed |
| pubmed-article:9827903 | pubmed:author | pubmed-author:BremondJ LJL | lld:pubmed |
| pubmed-article:9827903 | pubmed:author | pubmed-author:BinetCC | lld:pubmed |
| pubmed-article:9827903 | pubmed:author | pubmed-author:DomenechJJ | lld:pubmed |
| pubmed-article:9827903 | pubmed:author | pubmed-author:SensebeLL | lld:pubmed |
| pubmed-article:9827903 | pubmed:author | pubmed-author:ColombatPP | lld:pubmed |
| pubmed-article:9827903 | pubmed:author | pubmed-author:DegenneMM | lld:pubmed |
| pubmed-article:9827903 | pubmed:author | pubmed-author:BernardM CMC | lld:pubmed |
| pubmed-article:9827903 | pubmed:author | pubmed-author:HeraultOO | lld:pubmed |
| pubmed-article:9827903 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9827903 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:9827903 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9827903 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9827903 | pubmed:pagination | 343-50 | lld:pubmed |
| pubmed-article:9827903 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:9827903 | pubmed:meshHeading | pubmed-meshheading:9827903-... | lld:pubmed |
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| pubmed-article:9827903 | pubmed:meshHeading | pubmed-meshheading:9827903-... | lld:pubmed |
| pubmed-article:9827903 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9827903 | pubmed:articleTitle | All-trans-retinoic acid up-regulates CD38 but not c-Kit antigens on human marrow CD34+ cells without recruitment into cell cycle. | lld:pubmed |
| pubmed-article:9827903 | pubmed:affiliation | JE 1993, Faculty of Medicine, Tours, France. | lld:pubmed |
| pubmed-article:9827903 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9827903 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
