| pubmed-article:9826744 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9826744 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9826744 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:9826744 | lifeskim:mentions | umls-concept:C0162594 | lld:lifeskim |
| pubmed-article:9826744 | lifeskim:mentions | umls-concept:C2260797 | lld:lifeskim |
| pubmed-article:9826744 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:9826744 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:9826744 | pubmed:dateCreated | 1999-2-3 | lld:pubmed |
| pubmed-article:9826744 | pubmed:abstractText | IgG purified from sera of several patients with systemic lupus erythematosus and hepatitis B are shown to present RNA hydrolyzing activities that are different from the weak RNase A-type activities found in the sera of healthy donors. Further investigation brings evidence for two intrinsic activities, one observed in low salt conditions and another specifically stimulated by Mg2+ions and distinguishable from human sera RNases. Cleavage of RNA substrates by the latter activity is not sequence-specific but sensitive to both subtle conformational and/or drastic folding changes, as evidenced by comparative analysis of couples of structurally well-studied RNA substrates. These include yeast tRNAAsp and its in vitro transcript and human mitochondrial tRNALys-derived in vitro transcripts. The discovery of catalytic antibodies with RNase activities is a first step towards creation of a new generation of tools for the investigation of RNA structure. | lld:pubmed |
| pubmed-article:9826744 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9826744 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9826744 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9826744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9826744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9826744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9826744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9826744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9826744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9826744 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9826744 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9826744 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:9826744 | pubmed:author | pubmed-author:GiegéRR | lld:pubmed |
| pubmed-article:9826744 | pubmed:author | pubmed-author:HeldFF | lld:pubmed |
| pubmed-article:9826744 | pubmed:author | pubmed-author:NevinskyGG | lld:pubmed |
| pubmed-article:9826744 | pubmed:author | pubmed-author:FlorentzCC | lld:pubmed |
| pubmed-article:9826744 | pubmed:author | pubmed-author:NaumovVV | lld:pubmed |
| pubmed-article:9826744 | pubmed:author | pubmed-author:VlassovAA | lld:pubmed |
| pubmed-article:9826744 | pubmed:author | pubmed-author:BunevaVV | lld:pubmed |
| pubmed-article:9826744 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9826744 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9826744 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:9826744 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9826744 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9826744 | pubmed:pagination | 5243-50 | lld:pubmed |
| pubmed-article:9826744 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9826744 | pubmed:meshHeading | pubmed-meshheading:9826744-... | lld:pubmed |
| pubmed-article:9826744 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9826744 | pubmed:articleTitle | Characterization and selectivity of catalytic antibodies from human serum with RNase activity. | lld:pubmed |
| pubmed-article:9826744 | pubmed:affiliation | UPR 9002 du CNRS, Institut de Biologie Moléculaire et Cellulaire, 15, rue René Descartes, 67084 Strasbourg Cedex, France. | lld:pubmed |
| pubmed-article:9826744 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9826744 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9826744 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9826744 | lld:pubmed |
