| pubmed-article:9824721 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9824721 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:9824721 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9824721 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9824721 | lifeskim:mentions | umls-concept:C0026845 | lld:lifeskim |
| pubmed-article:9824721 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9824721 | lifeskim:mentions | umls-concept:C0205184 | lld:lifeskim |
| pubmed-article:9824721 | lifeskim:mentions | umls-concept:C0205144 | lld:lifeskim |
| pubmed-article:9824721 | pubmed:dateCreated | 1999-3-3 | lld:pubmed |
| pubmed-article:9824721 | pubmed:abstractText | 1. Changes in membrane potential following electrical field stimulation (EFS; 1, 2 and 5 pulses at 5 Hz, 0.5 ms duration, 60-80 V) of non-adrenergic non-cholinergic (NANC) inhibitory nerves in the rat isolated anococcygeus muscle were measured using standard intracellular recording techniques. Resting membrane potential ranged between -60 and -70 mV. 2. In the presence of guanethidine (30 microM), atropine (1 microM), propranolol (1 microM) and phentolamine (0.05 microM) to establish NANC conditions, the membrane potential depolarized to between -40 and -50 mV. Under these conditions, EFS caused pulse-dependent, tetrodotoxin (1 microM)-sensitive biphasic inhibitory junction potentials (IJPs) comprising a fast onset and time-to-peak phase followed by a second, slower phase that delayed repolarization. The duration of NANC IJPs ranged between 10 and 20 s. 3. Inhibition of small-conductance Ca2+-activated K+ channels with apamin (0.1 microM) selectively blocked the first fast phase of the NANC IJP, whereas inhibitors of large-conductance Ca2+-activated K+ channels (charybdotoxin and iberiotoxin) and ATP-sensitive K+ channels (glibenclamide) all had no effect on NANC IJPs. 4. Both the nitric oxide synthase inhibitor N G-nitro-L-arginine (L-NOARG; 100 microM) and the inhibitor of soluble guanylate cyclase 1-H-oxodiazol-[1,2,4]-[4,3-a] quinoxaline-1-one (ODQ; 10 microM) had no effect on the first fast phase of the NANC IJP. Each treatment, however, markedly inhibited the slow phase with the duration of the IJP reduced to between 1 and 3 s. The L-NOARG-resistant fast phase of the NANC IJP was almost abolished by the subsequent addition of apamin (0.1 microM). 5. In conclusion, the present study demonstrates unequivocal NANC nerve-mediated biphasic IJPs in the rat isolated anococcygeus. We propose that nitric oxide (NO), via activation of cGMP-dependent K+ channels, and a non-NO inhibitory factor which activates apamin-sensitive K+ channels contribute to NANC nerve-evoked IJPs in the rat anococcygeus. | lld:pubmed |
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| pubmed-article:9824721 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9824721 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9824721 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9824721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9824721 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9824721 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9824721 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:9824721 | pubmed:author | pubmed-author:CocksT MTM | lld:pubmed |
| pubmed-article:9824721 | pubmed:author | pubmed-author:ZiogasJJ | lld:pubmed |
| pubmed-article:9824721 | pubmed:author | pubmed-author:SelemidisSS | lld:pubmed |
| pubmed-article:9824721 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9824721 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9824721 | pubmed:volume | 513 ( Pt 3) | lld:pubmed |
| pubmed-article:9824721 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9824721 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9824721 | pubmed:pagination | 835-44 | lld:pubmed |
| pubmed-article:9824721 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9824721 | pubmed:meshHeading | pubmed-meshheading:9824721-... | lld:pubmed |
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| pubmed-article:9824721 | pubmed:meshHeading | pubmed-meshheading:9824721-... | lld:pubmed |
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| pubmed-article:9824721 | pubmed:meshHeading | pubmed-meshheading:9824721-... | lld:pubmed |
| pubmed-article:9824721 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9824721 | pubmed:articleTitle | Apamin- and nitric oxide-sensitive biphasic non-adrenergic non-cholinergic inhibitory junction potentials in the rat anococcygeus muscle. | lld:pubmed |
| pubmed-article:9824721 | pubmed:affiliation | Department of Pharmacology, Triradiate Building, University of Melbourne, Parkville, Victoria 3052, Australia. | lld:pubmed |
| pubmed-article:9824721 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9824721 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
